55104-35-3

Basic information

• Product Name: 5-HYDROXYPHTHALIDE
• Synonyms: AKOS 243-35;5-HYDROXYPHTHALIDE;Nsc28671;1(3H)-Isobenzofuranone,5-hydroxy-;5-hydroxy-3H-2-benzofuran-1-one
• CAS NO: 55104-35-3
• Molecular Formula: C₈H₆O₃
• Molecular Weight: 150.13
• Mol File: 55104-35-3.mol
• Article Data: 8

Chemical Properties

• Melting Point: 223-224 °C
• Boiling Point: 435.1°C at 760 mmHg
• Flash Point: 211.7°C
• Appearance: /
• Density: 1.436g/cm³
• Vapor Pressure: 3.53E-08mmHg at 25°C
• Refractive Index: 1.635
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 8.05±0.20(Predicted)
• CAS DataBase Reference: 5-HYDROXYPHTHALIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-HYDROXYPHTHALIDE(55104-35-3)
• EPA Substance Registry System: 5-HYDROXYPHTHALIDE(55104-35-3)

Safety Data

• Hazardous Substances Data: 55104-35-3(Hazardous Substances Data)

Usage

Description

5-HYDROXYPHTHALIDE is a heterocyclic compound belonging to the class of phthalides. It is characterized by the presence of a hydroxyl group attached to a phthalide structure, which is a cyclic ester derived from phthalic acid. This unique chemical structure endows 5-HYDROXYPHTHALIDE with versatile properties and potential applications in various fields.

Uses

Used in Organic Synthesis:
5-HYDROXYPHTHALIDE is used as an intermediate in organic synthesis for the production of various chemical compounds. Its reactive hydroxyl group and phthalide structure make it a valuable building block for the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5-HYDROXYPHTHALIDE is used as a key intermediate in the synthesis of drugs with potential therapeutic applications. Its unique chemical structure allows for the development of novel drug candidates with improved pharmacological properties, such as enhanced bioavailability, selectivity, and reduced side effects.
Used in Agrochemical Industry:
5-HYDROXYPHTHALIDE also finds application in the agrochemical industry as an intermediate for the synthesis of various pesticides and other crop protection agents. Its incorporation into these compounds can lead to improved efficacy, reduced environmental impact, and better target selectivity.
Used in Specialty Chemicals:
In the specialty chemicals sector, 5-HYDROXYPHTHALIDE is utilized as a starting material for the development of high-value products, such as dyes, pigments, and additives for various industries, including plastics, coatings, and textiles. Its versatile chemical structure allows for the creation of innovative and high-performing specialty chemicals with unique properties and applications.

InChI:InChI=1/C8H6O3/c9-6-1-2-7-5(3-6)4-11-8(7)10/h1-3,9H,4H2

Upstream product

• 65399-05-5 5-amino-3H-isobenzofuran-1-one 
• 610-35-5 4-hydroxyphthalic acid 
• 201230-82-2 carbon monoxide 
• 620-24-6 3-Hydroxybenzyl alcohol 
• 134418-62-5 (2-carbomethoxy-5-hydroxyphenyl)methyl 2-nitrobenzenesulfenate 
• 89-08-7 4-sulfophthalic acid 
• 483-84-1 8-hydroxy-5,7-dinitro-2-naphthalenesulfonic acid 
• 88-99-3 benzene-1,2-dicarboxylic acid 
• 4741-62-2 5-methoxyisobenzofuran-1(3H)-one 
• 28281-76-7 5-methoxyisobenzofuran-1,3-dione 
• 1428478-76-5 tert-butyl 4-tert-butoxy-2-methylbenzoate 
• 578-39-2 4-hydroxy-2-methylbenzoic acid 
• 1428478-77-6 tert-butyl 2-bromomethyl 4-tert-butoxybenzoate 
• 1411945-89-5 5-tert-butoxy-2-benzofuran-1-(3H)-one 

Downstream Products

• 1359669-78-5 tert-butyl [5-(benzyloxy)-1-hydroxy-1,3-dihydro-2-benzofuran-1-yl]acetate 
• 1359669-80-9 tert-butyl [5-(benzyloxy)-1,3-dihydro-2-benzofuran-1-yl]acetate 
• 1359669-90-1 tert-butyl (5-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-1,3-dihydro-2-benzofuran-1-yl)acetate 
• 1359669-13-8 (5-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-1,3-dihydro-2-benzofuran-1-yl)acetic acid 
• 1359669-02-5 5-(benzyloxy)-2-benzofuran-1(3H)-one 
• 1428478-80-1 tert-butyl 4-{[(1-oxo-1,3-dihydro-2-benzofuran-5-yl)oxy]methyl}piperidine-1-carboxylate 

Relevant articles and documents

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

no abstract published

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

This invention relates to compounds having structural Formula I: and pharmaceutically acceptable salts thereof which are inhibitors of the Renal Outer Medullary Potassium (ROMK) channel (Kirl.1). The compounds of Formula I are useful as diuretics and natriuretics and therefore are useful for the therapy and prophylaxis of disorders resulting from excessive salt and water retention, including cardiovascular diseases such as hypertension and chronic and acute heart failure

Synthesis and blocking activities of isoindolinone- and isobenzofuranone-containing phenoxylalkylamines as potent α1- adrenoceptor antagonists

This paper describes the synthesis and blocking activities of twelve new isoindolinone- and isobenzofura-none-containing phenoxylalkylamines as potent α1-Adrenoceptor antagonists. These compounds were synthesized in moderate to good yields starting from 3,4-dimethylphenol, and characterized with 1H-NMR, MS, IR and elemental analysis. Their blocking activities toward α1-Adrenoceptors were evaluated on isolated rat anococcygeus muscles. The results indicated that these compounds were very strong in blocking α1-Adrenoceptors, and most of them exhibited activities that were comparable to that of known potent α1- Adrenoceptor antagonist 1-(2,6-dimethylphenoxy)-2-(3,4- dimethoxyphenylethylamino)propane hydrochloride (DDPH).