552850-11-0

Basic information

• Product Name: C₅₅H₉₀BrNO₁₁Si₂
• Synonyms: C₅₅H₉₀BrNO₁₁Si₂
• CAS NO: 552850-11-0
• Molecular Weight: 1077.39
• Mol File: 552850-11-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₅₅H₉₀BrNO₁₁Si₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₅₅H₉₀BrNO₁₁Si₂(552850-11-0)
• EPA Substance Registry System: C₅₅H₉₀BrNO₁₁Si₂(552850-11-0)

Safety Data

• Hazardous Substances Data: 552850-11-0(Hazardous Substances Data)

Upstream product

• 201854-68-4 1-[6-allyl-4-(4-methoxy-benzyloxy)-3,5-dimethyl-tetrahydropyran-2-yl]-ethane-1,2-diol 
• 657389-88-3 (2R,3R,4R,5R,6S)-2-allyl-6-((S)-1-tert-butyldimethylsilanyloxyethyl)-4-(4-methoxy-benzyloxy)-3,5-dimethyltetrahydropyran 
• 657389-53-2 (2R,3R,4R,5R,6S)-2-(2-oxoethyl)-6-((S)-1-tert-butyldimethylsilanyloxyethyl)-4-(4-methoxy-benzyloxy)-3,5-dimethyltetrahydropyran 
• 657389-54-3 (S)-1-[(2R,3R,4S,5S,6R)-6-(2,2-Dimethoxy-ethyl)-4-(4-methoxy-benzyloxy)-3,5-dimethyl-tetrahydro-pyran-2-yl]-ethanol 
• 657389-52-1 (2R,3R,4R,5R,6S)-2-allyl-6-((S)-1-hydroxyethyl)-4-(4-methoxy-benzyloxy)-3,5-dimethyltetrahydropyran 
• 213978-64-4 3-O-(4'-methoxy-benzyl)-2-deoxy-4,5-O-isopropylidene-D-threo-pentose diethyl dithioacetal 
• 657389-99-6 4-(bromomethyl)-2-methyl-1,3-oxazole 
• 641613-68-5 2-((R)-2-methoxypent-4-ynylsulfanyl)benzothiazole 
• 552850-08-5 (1R,4R,10R,12R,1E,5E,7E)-1-bromo-9-(tert-butyldimethylsilanyloxy)-10-(4-methoxybenzyloxy)-7-methyl-4,12,12,14-tetramethoxytetradeca-1,5,7-triene 
• 552849-99-7 4-{(E)-2-[(2R,3R,4S,5S,6R)-6-(2,2-Dimethoxy-ethyl)-4-(4-methoxy-benzyloxy)-3,5-dimethyl-tetrahydro-pyran-2-yl]-propenyl}-2-methyl-oxazole 
• 552849-97-5 (2R,3R,4R,5R,6R)-2-(2-dimethoxyethylacetal)-6-(1-oxoethyl)-4-(4-methoxy-benzyloxy)-3,5-dimethyltetrahydropyran 
• 552849-98-6 dimethyl ((2-methyloxazol-4-yl)methyl)phosphonate 
• 296785-24-5 (4E)(2R)-1-(benzothiazol-2-ylsulfonyl)-5-bromo-2-(methoxy)-pent-4-ene 
• 657389-77-0 (4E)(2R)-1-(benzothiazol-2-ylsulfinyl)-5-bromo-2-(methoxy)-pent-4-ene 

Downstream Products

• 552850-01-8 C₅₃H₈₄BrNO₁₀Si₂ 

Relevant articles and documents

Total synthesis of (+)-phorboxazole A, a potent cytostatic agent from the sponge Phorbas sp.

A convergent total synthesis of phorboxazole A (1a), from the C(3-19), C(20-27) and C(33-46) fragments 5, 4 and 91, respectively, concentrating on stereocontrolled formation of the bonds at C(2-3), C(19-20) and C(27-28), is described. Although a coupling reaction between a macrolide ketone and the side chain substituted sulfone, at C(27-28) was not successful, a Wadsworth-Emmons olefination involving the oxane methyl ketone 4 and an oxazole produced the oxane 90 which was next coupled to 91 leading to the C(20-46) unit 100. A further coupling of 100 to 71c at C(19-20) then led to 105, ultimately, and the synthesis was completed by a macrocyclisation reaction from 105, at the C(2-3) alkene bond, followed by deprotection of 106.