55289-05-9

Basic information

• Product Name: METHYL 3-HYDROXY-2-METHYLBENZOATE
• Synonyms: METHYL 3-HYDROXY-2-METHYLBENZOATE;Methyl 2-methyl-3-hydroxybenzoate;3-Hydroxy-2-methylbenzoic acid methyl ester;Benzoic acid, 3-hydroxy-2-methyl-, methyl ester
• CAS NO: 55289-05-9
• Molecular Formula: C₉H₁₀O₃
• Molecular Weight: 166.1739
• EINECS: 200-258-5
• Product Categories: Aromatic Esters
• Mol File: 55289-05-9.mol
• Article Data: 41

Chemical Properties

• Melting Point: 66-67 °C(Solv: hexane (110-54-3))
• Boiling Point: 282.2±20.0 °C(Predicted)
• Appearance: /
• Density: 1.169±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 9.50±0.10(Predicted)
• CAS DataBase Reference: METHYL 3-HYDROXY-2-METHYLBENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 3-HYDROXY-2-METHYLBENZOATE(55289-05-9)
• EPA Substance Registry System: METHYL 3-HYDROXY-2-METHYLBENZOATE(55289-05-9)

Safety Data

• Hazardous Substances Data: 55289-05-9(Hazardous Substances Data)

Usage

General Description

Methyl 3-hydroxy-2-methylbenzoate is a compound with the chemical formula C9H10O3. It is a methyl ester derivative of 3-hydroxy-2-methylbenzoic acid and is commonly used as a flavoring agent in food and beverages. It is also used in the synthesis of various pharmaceuticals and as a fragrance ingredient in cosmetics and personal care products. Methyl 3-hydroxy-2-methylbenzoate has a sweet, fruity odor and is known for its pleasant aroma and taste. It is important to handle this chemical with caution, as it may cause irritation to the skin, eyes, and respiratory system if not properly handled.

Upstream product

• 67-56-1 methanol 
• 603-80-5 3-hydroxy 2-methylbenzoic acid 
• 18583-89-6 methyl 3-amino-2-methylbenzoate 
• 59382-59-1 2-methyl-3-nitro-benzoic acid methyl ester 
• 1975-50-4 2-methyl-3-nitrobenzic acid 
• 52130-17-3 3-amino-2-methylbenzoic acid 
• 3260-87-5 3-chloro-o-cresol 
• 55289-04-8 3-hydroxy-2-methylbenzonitrile 
• 75-36-5 acetyl chloride 
• 144-55-8 sodium hydrogencarbonate 
• 1120-73-6 2-methyl-2-cyclopenten-1-one 
• 95-47-6 o-xylene 
• 83-41-0 2,3-dimethylnitrobenzene 

Downstream Products

• 104216-90-2 3-ethoxy-2-methyl-benzoic acid methyl ester 
• 134154-59-9 methyl 2-methyl-3-(naphth-2-ylmethoxy)benzoate 
• 55289-15-1 methyl 6-bromo-3-hydroxy-2-methylbenzoate 
• 55289-06-0 3-methoxy-2-methylbenzoic acid 
• 42981-93-1 3-methoxy-2-methylbenzoic acid methyl ester 
• 467252-04-6 methyl 3-isobutoxy-2-methylbenzoate 
• 467252-57-9 methyl 2-methyl-3-(2-morpholinoethoxy)benzoate 
• 339354-86-8 methyl 3-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}-2-methylbenzoate 
• 467252-56-8 methyl 3-[2-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]-2-methylbenzoate 
• 948837-59-0 C₁₅H₂₃O₃BrSi 
• 948837-48-7 C₁₄H₂₃O₂BrSi 
• 948837-60-3 C₁₉H₃₁O₃BrSi 
• 948837-49-8 C₂₀H₃₂O₄Si 
• 948837-50-1 C₂₆H₄₀O₅Si 

Relevant articles and documents

Synthesis process 2 - methyl -3 - methoxybenzoic acid

The invention discloses a synthesis process of 2 - methyl -3 - methoxybenzoic acid, which comprises the following steps: (1) reducing hydrogenation reaction: taking 2 - methyl -3 - nitrobenzoic acid or 2 - methyl -3 - nitrobenzoate as raw materials and methanol as a solvent. The hydrogen is a hydrogen source, and palladium carbon or platinum carbon is used as a catalyst to prepare 3 - amino -2 - methyl benzoic acid or 3 - amino -2 - methyl benzoic acid methyl ester by hydrogenation reduction. (2) Diazotization and hydrolysis and esterification one-pot reaction: preparing and hydroxyl 3 - methyl benzoic acid methyl ester by carrying out diazotization and hydrolysis -2 - esterification reaction under the action of a reducing product as a raw material and methanol as a solvent and a diazotization reagent. (3) Methylation reaction: methyl benzoate serving 3 - hydroxyl -2 - is used as a raw material, dimethyl sulfate is used as a methylation reagent, and methyl benzoate is produced 3 - methoxy -2 - methyl benzoate in the presence of a base. (4) Hydrolysis Reaction: methyl 3 - methoxy -2 - methyl benzoate and base. Water is mixed, heated and hydrolyzed, the reaction is complete, the product precipitated by acid conditioning PH through 1-3, filtered, and dried to obtain 3 - methoxy -2 -methylbenzoic acid.

Influence of Linker Attachment Points on the Stability and Neosubstrate Degradation of Cereblon Ligands

Proteolysis targeting chimeras (PROTACs) hijacking the cereblon (CRBN) E3 ubiquitin ligase have emerged as a novel paradigm in drug development. Herein we found that linker attachment points of CRBN ligands highly affect their aqueous stability and neosubstrate degradation features. This work provides a blueprint for the assembly of future heterodimeric CRBN-based degraders with tailored properties.

DEGRADERS OF WEE1 KINASE

Disclosed are bifunctional compounds (degraders) that target Wee1 tyrosine kinase for degradation. Also disclosed are pharmaceutical compositions containing the degraders and methods of using the compounds to treat disease.