55310-46-8Relevant articles and documents
Dibenzylammonium and Sodium Dibenzyldithiocarbamates as Precipitants for Preconcentration of Trace Elements in Water for Analysis by Energy Dispersive X-ray Fluorescence
Moore, Robert V.
, p. 895 - 897 (1982)
Precipitation with combined dibenzylammonium dibenzyldithiocarbamate and sodium dibenzyldithiocarbamate at pH 5.0 can be used to separate 22 trace elements from water.Membrane filtration of the precipitate yielded a thin sample, suitable for analysis by energy dispersive X-ray fluorescence spectrometry.Alkalis, alkaline earths, lanthanides, and halides were not precipitated, permitting a clean separation of trace elements from the macro constituents of drinking water and drinking water supplies.Methods are given for preparation of reagents of higher purity than previo usly described.
Dithiocarbamates combined with copper for revitalizing meropenem efficacy against NDM-1-producing Carbapenem-resistant Enterobacteriaceae
Chen, Cheng,Yang, Ke-Wu,Zhai, Le,Ding, Huan-Huan,Chigan, Jia-Zhu
supporting information, (2021/11/20)
The worldwide prevalence of NDM-1-producing Gram-negative pathogens has drastically undermined the clinical efficacy of carbapenems, prompting a need to devise an effective strategy to preserve their clinical value. Here we constructed a focused compound library of dithiocarbamates and systematically evaluated their potential synergistic antibacterial activities combined with copper. SA09-Cu exhibited excellent inhibition against a series of clinical NDM-1-producing carbapenem-resistant Enterobacteriaceae (CRE) in restoring meropenem effect, and slowed down the development of carbapenem resistance. Enzymatic kinetic and isothermal titration calorimetry studies demonstrated that SA09-Cu was a noncompetitive NDM-1 inhibitor. The electron paramagnetic resonance (EPR) and X-ray photoelectron spectroscopy (XPS) revealed a novel inhibition mechanism, which is that SA09-Cu could convert NDM-1 into an inactive state by oxidizing the Zn(II)-thiolate site of the enzyme. Importantly, SA09-Cu showed a unique redox tuning ability, and avoided to be reduced by intracellular thiols of bacteria. In vivo experiments indicated that SA09 combined with CuGlu could effectively potentiate MER's effect against NDM-1-producing E. coli (EC23) in the murine infection model. This study provides a highly promising scaffold in developing novel inhibitors to combat NDM-1-producing CREs.
TRIAZINANE DERIVATIVES AND METHODS OF MAKING THEM
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Paragraph 0052, (2021/03/05)
The present invention is directed to compounds represented by the formula I: wherein R1comprises a hydrogen atom or an alkyl group having 1 to 2 carbon atoms; wherein R2 comprises an alkylene group, an arylene group, or a heterocyclic group; and wherein R3, R4, R5, R6, R7, and R8 are identical or different and comprise a hydrogen atom, an alkyl group, an aryl group, or an alkylaryl group.
Method for preparing tetrabenzyl thiuram disulfide
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Paragraph 0008; 0023; 0027-0028; 0032; 0036; 0040; 0043, (2021/11/21)
The invention belongs to the technical field of rubber auxiliary production, and relates to a method for preparing a disulphide tetrabenzyl thiuram disulfide. The method comprises the following steps: sequentially adding water, an aqueous sodium hydroxide solution and dibenzylamine in a reactor, adding a dispersing agent, and then dropwise adding carbon disulfide to perform condensation reaction to obtain the dibenzyldithioformate solution. The sodium dibenzyldithioformate solution is subjected to oxidation reaction and then filtered and dried to obtain a thiurylthiuram disulfide. In the condensation reaction process, the dispersing agent is added, the reaction system forms a uniform state, the reaction process is carried out in a uniform system, two-phase reaction is avoided when carbon disulfide is added dropwise in the prior art, and the reaction effect is poor. COD In the waste water is low, easily waste water treatment. The obtained disulfide tetrabenzylthiuram product has the appearance of white powder and the purity 98% or more.