55330-46-6Relevant articles and documents
Silver-promoted regio- and stereoselective aminocyanation of alkynes for the synthesis of β-aminoacrylonitriles using N-isocyanoiminotriphenylphosphorane
Chen, Lingnan,Cao, Shanshan,Zhang, Jingping,Wang, Zikun
supporting information, p. 1678 - 1681 (2019/05/29)
The silver-promoted intermolecular aminocyanation of alkynes for the synthesis of (Z)-β-aminoacrylonitriles is reported, using N-isocyanoiminotriphenylphosphorane (NIITP) as both the nitrile and amine source. The transformation proceeds in moderate to good yields, and in a regio- and stereoselective manner, using a wide range of acetylenes.
Rhodium-catalyzed asymmetric hydrogenation of β-acetylamino acrylonitriles
Ma, Miaofeng,Hou, Guohua,Wang, Junru,Zhang, Xumu
experimental part, p. 506 - 511 (2011/06/17)
The rhodium-catalyzed asymmetric hydrogenation of β-acetylamino acrylonitriles was investigated by using monophosphine and bisphosphine ligands. It was found that an Rh-QuinoxP complex exhibited high enantioselectivities for β-aryl substituted β-acetylamino acrylonitriles and the Rh-JosiPhos CyPF-t-Bu complex was proven to be effective for the hydrogenation of tetrasubstituted olefins from cyclic β-acetylamino acrylonitriles.
Highly efficient RhI-catalyzed asymmetric hydrogenation of β-amino acrylonitriles
Ma, Miaofeng,Hou, Guohua,Sun, Tian,Zhang, Xiaowei,Li, Wei,Wang, Junru,Zhang, Xumu
supporting information; experimental part, p. 5301 - 5304 (2010/09/08)
(Figure Presented) It takes two to TangPhos: β-Amino acrylonitriles can be readily prepared from acetonitriles. Both of the E/Z isomers undergo hydrogenation with excellent enantioselectivity by using the Rh-TangPhos (TangPhos = l, 1'-ditert-butyl-(2, 2')-diphospholane) catalyst system. The products, chiral β-amino nitriles, are valuable chiral building blocks for many drugs.
