5534-18-9 Usage
Description
9-chloro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate, also known as Beclomethasone Dipropionate (BDP), is a synthetic corticosteroid used in the treatment of various medical conditions. It is an active metabolite of BDP, characterized by its light yellow solid appearance. 9-chloro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate possesses potent anti-inflammatory and immunosuppressive properties, making it a valuable pharmaceutical agent.
Uses
Used in Pharmaceutical Industry:
9-chloro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate is used as an active metabolite for Beclomethasone Dipropionate. It is utilized in the treatment of various inflammatory and allergic conditions, such as asthma, chronic obstructive pulmonary disease (COPD), and allergic rhinitis. 9-chloro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate's anti-inflammatory and immunosuppressive properties help to alleviate symptoms and reduce inflammation in these conditions.
Used in Asthma Treatment:
In the field of respiratory medicine, 9-chloro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate is used as an anti-inflammatory agent for asthma treatment. It helps to reduce inflammation in the airways, leading to improved lung function and reduced symptoms in patients with asthma.
Used in COPD Management:
In the context of chronic obstructive pulmonary disease (COPD), this compound is used as a bronchodilator and anti-inflammatory agent. It helps to relax the muscles in the airways, improving airflow and reducing the frequency and severity of COPD exacerbations.
Used in Allergic Rhinitis Treatment:
9-chloro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate is also used as a treatment for allergic rhinitis, a common condition characterized by inflammation and irritation of the nasal passages. 9-chloro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate's anti-inflammatory properties help to alleviate symptoms such as sneezing, itching, and nasal congestion.
Check Digit Verification of cas no
The CAS Registry Mumber 5534-18-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,5,3 and 4 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 5534-18:
(6*5)+(5*5)+(4*3)+(3*4)+(2*1)+(1*8)=89
89 % 10 = 9
So 5534-18-9 is a valid CAS Registry Number.
5534-18-9Relevant articles and documents
Practical and scalable synthesis of beclomethasone dipropionate
Welideniya, Dhanushi T.,Jayathilaka, Adeesha S.,Acharige, Anjana Delpe,Samanthi,Wanninayake, Umayangani K.,Perera, Shashika S.,Rajapaksha, Weranga,Fernando, Chamod C.,Hewadikaram, Madhavi,Buddhika, Janani,Gunasekara, Pivini,Karunaratne, Veranja,Amaratunga,Gunasekera, Dinara S.
, (2021/12/22)
Beclomethasone dipropionate (1) is a synthetic corticosteroid with anti-inflammatory, antipruritic, and anti-allergy properties. It is widely used to treat asthma, allergic rhinitis, and dermatoses. However, existing synthetic routes to this active pharmaceutical ingredient (API) contain steps resulting in low and/or inconsistent yields, and use obsolete reagents. Such inconsistencies coupled with a lack of reliable experimental data makes laboratory-scale and large-scale synthesis of this API difficult and time-consuming. In this paper, we report a practical and scalable approach to synthesize 1 from the readily available steroidal intermediate, 16β-methyl epoxide (3, DB-11). A gram-scale to kilogram-scale synthesis of 1 was achieved with 82% yield, using a cost-effective and scalable methodology. Selective propionylation of the hydroxyl groups at C17 and C21 demonstrate the fact that this approach can be conveniently implemented in fine chemical industries.
