55438-67-0Relevant articles and documents
A Single-Step Synthesis of Azetidine-3-amines
Wang, Brian J.,Duncton, Matthew A. J.
, p. 13317 - 13323 (2020/11/26)
The azetidine group is frequently encountered within contemporary medicinal chemistry. However, the introduction of an azetidine can be synthetically challenging. Herein, a straightforward synthesis of azetidine-3-amines, starting from a bench stable, commercial material is presented. The reaction tolerates common functionality and proceeds in moderate-to-high yield with secondary amines, and moderate-to-low yield with primary amines. The methodology compares favorably to alternative procedures and can be utilized in "any-stage"functionalization, including late-stage azetidinylation of approved drugs and other compounds with pharmacological activity.
Thiophene derivatives useful as anticancer agents
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, (2008/06/13)
The invention relates to compounds of the formula 1 or a pharmaceutically acceptable salt and to pharmaceutically acceptable salts and hydrates thereof, wherein X, Y, R1, R2 and R11 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula 1.