55486-09-4 Usage
Description
5,2'-O-Dimethyluridine, also known as 5-Me-2'-OMe Uridine, is a methyluridine derivative featuring two methyl substituents located at position C-5 on the uracil ring and position O-2' on the ribose ring. It is one of the three oligonucleotides found in platinum-derivatized homopyrimidine triplex-forming oligonucleotides (Pt-TFOs), which are utilized for crosslinking to the transcribed strand in the human androgen receptor (AR) gene. Additionally, it exhibits inhibitory activity against M. bovis and M. avium.
Uses
Used in Gene Regulation:
5,2'-O-Dimethyluridine is used as a component in Pt-TFOs for gene regulation, specifically targeting the human androgen receptor (AR) gene. Its role in crosslinking to the transcribed strand allows for the manipulation of gene expression and has potential applications in gene therapy and the study of genetic disorders.
Used in Antimicrobial Applications:
In the field of microbiology, 5,2'-O-Dimethyluridine is utilized as an inhibitor against Mycobacterium bovis and Mycobacterium avium. Its inhibitory activity contributes to the development of new strategies for combating bacterial infections, particularly those caused by mycobacterial species.
Used in Pharmaceutical Research:
Due to its unique structure and properties, 5,2'-O-Dimethyluridine holds promise for pharmaceutical research. It can be employed as a building block in the development of novel drugs targeting various diseases, including genetic disorders and bacterial infections. Its potential applications in drug discovery and design make it a valuable compound for further investigation and development.
Check Digit Verification of cas no
The CAS Registry Mumber 55486-09-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,5,4,8 and 6 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 55486-09:
(7*5)+(6*5)+(5*4)+(4*8)+(3*6)+(2*0)+(1*9)=144
144 % 10 = 4
So 55486-09-4 is a valid CAS Registry Number.
55486-09-4Relevant articles and documents
SYNTHESIS AND STRUCTURE OF HIGH POTENCY RNA THERAPEUTICS
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, (2019/01/15)
This invention provides expressible polynucleotides, which can express a target protein or polypeptide. Synthetic mRNA constructs for producing a protein or polypeptide can contain one or more 5′ UTRs, where a 5′ UTR may be expressed by a gene of a plant. In some embodiments, a 5′ UTR may be expressed by a gene of a member of Arabidopsis genus. The synthetic mRNA constructs can be used as pharmaceutical agents for expressing a target protein or polypeptide in vivo.
Sugar conformational effects on the photochemistry of thymidylyl(3′-5′)thymidine
Ostrowski, Tomasz,Maurizot, Jean-Claude,Adeline, Marie-Therese,Fourrey, Jean-Louis,Clivio, Pascale
, p. 6502 - 6510 (2007/10/03)
The synthesis and conformational analysis of 2′-O,5-dimethyluridylyl(3′-5′)-2′-O,5-dimethyluridine (1a), the analogue of thymidylyl(3′-5′)thymidine (TpT; 1b) in which a methoxy group replaces each 2′-α-hydrogen atom, are described. In comparison with TpT, such modification increases the population of the C3′-endo conformer of the sugar ring puckering at the 5′- and 3′-ends from 30 to 75% and from 37 to 66%, respectively. Photolyses of 1a and TpT at 254 nm are qualitatively comparable (the cis-syn cyclobutane pyrimidine dimer and the (6-4) photoproduct are formed), although it is significantly faster in the case of 1a. These results are explained by the increased propensity of the modified dinucleotide to adopt a base-stacked conformation geometry reminiscent of that for TpT.
A novel and economical synthesis of 2′-o-alkyl-uridines
Ross, Bruce S.,Springer, Robert H.,Tortorici, Zeb,Dimock, Stuart
, p. 1641 - 1643 (2007/10/03)
A highly efficient, two-step method to make 2′-O-methyluridine is described using only inexpensive reagents and no chromatography. The method is applicable for some other alkyls as well as some other pyrimidine derivatives. Copyright
