55502-03-9

Basic information

• Product Name: 1-(4-BROMOBUTOXY)-4-NITROBENZENE
• Synonyms: 1-(4-BROMOBUTOXY)-4-NITROBENZENE;CHEMBRDG-BB 5477194;4-Nitrophenoxybutylbromide;1-(4-Bromobutoxy)-4-nitrobenzene,85%
• CAS NO: 55502-03-9
• Molecular Formula: C₁₀H₁₂BrNO₃
• Molecular Weight: 274.11
• Mol File: 55502-03-9.mol
• Article Data: 25

Chemical Properties

• Melting Point: 37-40 °C
• Boiling Point: 165-170 °C (0.5 mmHg)
• Flash Point: 186.7°C
• Appearance: Beige to brown/Adhering Chunks
• Density: 1.458g/cm³
• Vapor Pressure: 8.65E-06mmHg at 25°C
• Refractive Index: 1.563
• CAS DataBase Reference: 1-(4-BROMOBUTOXY)-4-NITROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-BROMOBUTOXY)-4-NITROBENZENE(55502-03-9)
• EPA Substance Registry System: 1-(4-BROMOBUTOXY)-4-NITROBENZENE(55502-03-9)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-22
• Safety Statements: 37/39-26
• Hazardous Substances Data: 55502-03-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H12BrNO3/c11-7-1-2-8-15-10-5-3-9(4-6-10)12(13)14/h3-6H,1-2,7-8H2

Upstream product

• 110-52-1 1,4-dibromo-butane 
• 1124-31-8 potassium 4-nitrophenolate 
• 100-02-7 4-nitro-phenol 
• 824-78-2 4-nitrophenol sodium salt 

Downstream Products

• 104296-36-8 5-(4-nitrophenoxy)pentanenitrile 
• 102449-79-6 α-<4-(4-Nitro-phenoxy)-butyl>-α-benzoyl-essigsaeure-aethylester 
• 125174-48-3 Methyl-[4-(4-nitro-phenoxy)-butyl]-[2-(4-nitro-phenyl)-ethyl]-amine 
• 168296-78-4 C₅₈H₆₄N₂O₁₄ 
• 125174-66-5 C₁₉H₂₇N₃O 
• 125174-82-5 N-[4-(2-{[4-(4-Methanesulfonylamino-phenoxy)-butyl]-methyl-amino}-ethyl)-phenyl]-methanesulfonamide 
• 103797-32-6 5-(4-nitrophenoxy)pentanoic acid 
• 99841-99-3 5-(4-nitro-phenoxy)-valeric acid amide 
• 103852-82-0 5-(4-amino-phenoxy)-valeric acid 
• 104396-54-5 6-(4-nitrophenoxy)-hexanoic acid 
• 101719-24-8 6-<4-Nitro-phenoxy>-1-phenyl-hexanol-(1) 
• 101730-39-6 6-(4-Nitro-phenoxy)-1-phenyl-hexanon-⁽¹⁾ 
• 101781-63-9 1-Phenyl-6-(4-amino-phenoxy)-hexanol-⁽¹⁾ 
• 47376-08-9 m-(p-Nitro-phenoxy-butoxy)-benzamidin 

Relevant articles and documents

Ratiometric Fluorescent Probe for Lysosomal pH Measurement and Imaging in Living Cells Using Single-Wavelength Excitation

A novel lysosome-targeting ratiometric fluorescent probe (CQ-Lyso) based on the chromenoquinoline chromorphore has been developed for the selective and sensitive detection of intracellular pH in living cells. In acidic media, the protonation of the quinol

Design, synthesis, biological evaluation and molecular dynamics simulation studies of (R)-5-methylthiazolidin-4-One derivatives as megakaryocyte protein tyrosine phosphatase 2 (PTP-MEG2) inhibitors for the treatment of type 2 diabetes

PTP-MEG2 plays a significant role in insulin production and is able to enhance insulin signaling and improve insulin sensitivity. So, PTP-MEG2 inhibitors are closely associated with type 2 diabetes therapy. A series of novel (R)-5-methylthiazolidin-4-one

Discovery of Diphenoxy Derivatives with Flexible Linkers as Ligands for β-Amyloid Plaques

The highly rigid and planar scaffolds with π-conjugated systems have been widely considered to be indispensable for β-amyloid (Aβ) binding ligands. In this study, a library of diphenoxy compounds with different types of more flexible linkers as Aβ ligands were synthesized and evaluated. Most of them displayed good affinity (Ki1-42aggregates, and some ligands even showed values of Kiless than 10 nM. Structure-activity relationship analysis revealed that modification on the linkers or substituents tolerated great flexibility, which challenged the long-held belief that rigid and planar structures are exclusively favored for Aβ binding. Three ligands were labeled by iodine-125, and they exhibited good properties in vitro and in vivo, which further supported that this flexible scaffold was potential and promising for the development of Aβ imaging agents.