55533-25-0Relevant articles and documents
BISAMINO BENZYLPIPERAZINE DIONE, AMIDE ACID POLYMER AND POLYIMIDE, AND HOLLOW POLYIMIDE PARTICLE AND MANUFACTURING METHOD THEREFOR
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Paragraph 0122; 0123; 0124; 0125, (2019/10/02)
PROBLEM TO BE SOLVED: To provide polyimide which is rigid, easily powdered, and excellent in chemical resistance, heat resistance, or the like, an amide acid polymer useful as a manufacturing intermediate of the polyimide, an amide acid polymer useful as
Development of active center-directed plasmin and plasma kallikrein inhibitors and studies on the structure-inhibitory activity relationship
Teno,Wanaka,Okada,Taguchi,Okamoto,Hijikata-Okunomiya,Okamoto
, p. 1079 - 1090 (2007/10/02)
The molecule of trans-4-aminomethylcyclohexanecarbonylphenylalanine 4- carboxymethylanilide (8), which is a potent and selective inhibitor of plasma kallikrein, can be divided into three parts (P1, P1 and P2), each of which contains one of the rings. In order to study the role of each part in the manifestation of potent and selective inhibitory activity and the relationship between the structure and inhibitory activities toward plasmin, plasma kallikrein, urokinase and thrombin, each part was substituted with various other moieties to give many kinds of analogs and their inhibitory activities against the above enzymes were examined. Among them, trans-4- aminomethylcyclohexanecarbonyl-O-2-bromobenzyloxycarbonyltyrosine 4- acetylanilide (12) inhibited plasmin and plasma kallikrein with IC50 values of 2.3 x 10-7 M and 3.7 x 10-7 M, and K(i) values of 1.2 x 10-7 M and 1.3 x 10-7 M, respectively.