55654-69-8

Basic information

• Product Name: N-ethyl-2-(1H-indol-3-yl)-2-oxoacetamide
• Synonyms: 1H-indole-3-acetamide, N-ethyl-alpha-oxo-
• CAS NO: 55654-69-8
• Molecular Formula: C₁₂H₁₂N₂O₂
• Molecular Weight: 216.2359
• Mol File: 55654-69-8.mol
• Article Data: 2

Chemical Properties

• Melting Point: 203-204 °C(Solv: ethanol (64-17-5))
• Density: 1.254g/cm³
• Refractive Index: 1.631
• PKA: 12.37±0.46(Predicted)
• CAS DataBase Reference: N-ethyl-2-(1H-indol-3-yl)-2-oxoacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-ethyl-2-(1H-indol-3-yl)-2-oxoacetamide(55654-69-8)
• EPA Substance Registry System: N-ethyl-2-(1H-indol-3-yl)-2-oxoacetamide(55654-69-8)

Safety Data

• Hazardous Substances Data: 55654-69-8(Hazardous Substances Data)

Upstream product

• 22980-09-2 indolyl-3-glyoxylyl chloride 
• 557-66-4 ethanamine hydrochloride 
• 120-72-9 indole 
• 75-04-7 ethylamine 

Downstream Products

• 615556-77-9 N-ethyl-2-oxo-2-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]acetamide 
• 61-53-0 5-fluoro-α-methyltryptamine 

Relevant articles and documents

Alpha-ethyltryptamines as dual dopamine-serotonin releasers

The dopamine (DA), serotonin (5-HT), and norepinephrine (NE) transporter releasing activity and serotonin-2A (5-HT2A) receptor agonist activity of a series of substituted tryptamines are reported. Three compounds, 7b, (+)-7d and 7f, were found to be potent dual DA/5-HT releasers and were >10-fold less potent as NE releasers. Additionally, these compounds had different activity profiles at the 5-HT2Areceptor. The unique combination of dual DA/5-HT releasing activity and 5-HT2Areceptor activity suggests that these compounds could represent a new class of neurotransmitter releasers with therapeutic potential.