55666-43-8 Usage
Description
T-BUTYL 3-BROMOPROPIONATE 97, also known as tert-butyl 3-bromopropionate, is an organic compound that serves as an important intermediate in the synthesis of various organic compounds. It is a colorless liquid with a molecular weight of approximately 167.04 g/mol and a density of around 1.15 g/cm3. Its chemical formula is C7H13BrO2, and it exhibits reactivity due to the presence of the bromine atom, making it a versatile building block in organic synthesis.
Uses
Used in Pharmaceutical Industry:
T-BUTYL 3-BROMOPROPIONATE 97 is used as a synthetic intermediate for the production of pharmaceutical compounds. Its ability to undergo various chemical reactions, such as nucleophilic substitution and elimination reactions, allows it to be a key component in the synthesis of complex organic molecules with potential therapeutic applications.
Used in Chemical Synthesis:
In the field of chemical synthesis, T-BUTYL 3-BROMOPROPIONATE 97 is used as a versatile reagent for the preparation of various organic compounds. Its reactivity and stability make it suitable for use in a wide range of reactions, including esterification, transesterification, and the formation of carbonates.
Used in Synthesis of tert-butyl-12-cholesteryloxi-4,7,10-trioxadodecanoate:
T-BUTYL 3-BROMOPROPIONATE 97 is used as a key intermediate in the synthesis of tert-butyl-12-cholesteryloxi-4,7,10-trioxadodecanoate, a compound with potential applications in the pharmaceutical industry. The bromine atom in T-BUTYL 3-BROMOPROPIONATE 97 can be replaced by a hydroxyl group, leading to the formation of the desired product.
Used in Synthesis of 2-(tert-butoxycarbonyl)ethyl 2,3,4-tri-O-acetyl-1-thio-α-L-fucopyranoside:
T-BUTYL 3-BROMOPROPIONATE 97 is also used in the synthesis of 2-(tert-butoxycarbonyl)ethyl 2,3,4-tri-O-acetyl-1-thio-α-L-fucopyranoside, a complex organic compound with potential applications in the field of carbohydrate chemistry. The tert-butyl group in T-BUTYL 3-BROMOPROPIONATE 97 can be utilized to protect the hydroxyl groups during the synthesis process, allowing for selective reactions to occur.
Check Digit Verification of cas no
The CAS Registry Mumber 55666-43-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,5,6,6 and 6 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 55666-43:
(7*5)+(6*5)+(5*6)+(4*6)+(3*6)+(2*4)+(1*3)=148
148 % 10 = 8
So 55666-43-8 is a valid CAS Registry Number.
InChI:InChI=1/C7H13BrO2/c1-7(2,3)10-6(9)4-5-8/h4-5H2,1-3H3
55666-43-8Relevant articles and documents
Fine-tuning water exchange on GdIII poly(amino carboxylates) by modulation of steric crowding
Jaszberenyi, Zoltan,Sour, Angelique,Toth, Eva,Benmelouka, Meriem,Merbach, Andre E.
, p. 2713 - 2719 (2005)
In the objective of optimizing water exchange rate on stable, nine-coordinate, monohydrated GdIII poly(amino carboxylate) complexes, we have prepared monopropionate derivatives of DOTA4- (DO3A-Nprop4-) and DTPA5- (DTTA-Nprop5-). A novel ligand, EPTPA-BAA3-, the bisamylamide derivative of ethylenepropylenetriaminepentaacetate (EPTPA5-) was also synthesized. A variable temperature 17O NMR study has been performed on their GdIII complexes, which, for [Gd(DTTA-Nprop)(H2O)] 2- and [Gd(EPTPA-BAA)(H2O)] has been combined with multiple field EPR and NMRD measurements. The water exchange rates, k ex298, are 8.0 × 107 s-1, 6.1 × 107 s-1 and 5.7 × 107 s -1 for [Gd(DTTA-Nprop)(H2O)]2-, [Gd(DO3A-Nprop)(H2O)]- and [Gd(EPTPA-BAA)(H 2O)], respectively, all in the narrow optimal range to attain maximum proton relaxivities, provided the other parameters (electronic relaxation and rotation) are also optimized. The substitution of an acetate with a propionate arm in DTPA5- or DOTA4- induces increased steric compression around the water binding site and thus leads to an accelerated water exchange on the GdIII complex. The kex values on the propionate complexes are, however, lower than those obtained for [Gd(EPTPA)(H2O)]2- and [Gd(TRITA)(H2O)] - which contain one additional CH2 unit in the amine backbone as compared to the parent [Gd(DTPA)(H2O)]2- and [Gd(DOTA)(H2O)]-. In addition to their optimal water exchange rate, [Gd(DTTA-Nprop)(H2O)]2- has, and [Gd(DO3A-Nprop)(H2O)]- is expected to have sufficient thermodynamic stability. These properties together make them prime candidates for the development of high relaxivity, macromolecular MRI contrast agents. The Royal Society of Chemistry 2005.
Thrombin inhibitors
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Page column 29, (2010/02/06)
Novel five-membered heterocyclic amidines, their preparation and use as competitive inhibitors of trypsin-like serine proteases, especially thrombin and kininogenases such as kallikrein. Pharmaceutical compositions which contain the compounds as active ingredients, and use of the compounds as thrombin inhibitors, anticoagulants and antiinflammatory agents.
Sulfonyl isatin compounds and methods of blocking apoptosis therewith
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, (2008/06/13)
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