55667-43-1Relevant articles and documents
NEW ROUTES TO 1,1-DICHLORO-4-METYL-1,3-PENTADIENE
Bitter, Istvan,Toeke, Laszlo,Bende, Zoltan,Karpati-Adam, Eva,Soos, Rudolf
, p. 4501 - 4506 (1984)
1,1,1-trichloro-2-hydroxy-4-methyl-pentene-3 (1b) was chlorinated to afford tri- and tetra-chlorinated compounds 2,3,4.Compounds 2 and 3 were transformed by reductive dechlorination into 1,1-dichloro-4-methyl-1,3-pentadiene.Another route starting from the same alcohol or its isomer was also developed.
Liebeskind-Srogl cross-coupling on γ-carboxyl-γ-butyrolactone derivatives: Application to the side chain of amphidinolides C and F
Fenneteau, Johan,Vallerotto, Sara,Ferrié, Laurent,Figadère, Bruno
, p. 3758 - 3761 (2015/06/08)
The synthetic approach for the C20-C29 and C20-C34 fragments of amphidinolide F and C was based on an original Liebeskind-Srogl cross-coupling reaction with a glutamic acid-derived building-block. Further highly diastereoselective reduction of the ketone was achieved by using an uncommon Ph3SiH/TBAF/HMPA system. The amphidinolide C side chain was built through a reductive elimination of chiral epoxide to install the stereogenic center at C29.
Electrochemical Synthesis of 1,1-Dichloro-4-methylpenta-1,3-diene
Fechtel, U.,Matschiner, H.
, p. 545 - 551 (2007/10/02)
Reaction of 1,1,1-trichloro-4-methylpent-3-en-2-ol (2) with inorganic acid halides yielded several polychloroalkenes (3-5).These compounds were utilized for the electrochemical synthesis of 1,1-dichloro-4-methylpenta-1,3-diene (1).