55689-64-0

Basic information

• Product Name: 6,11-dihydro-11-oxo-dibenz[b,e]oxepin-2-acetate,methyl ester
• Synonyms: 6,11-dihydro-11-oxo-dibenz[b,e]oxepin-2-acetate,methyl ester;METHYL 6,11-DIHYDRO-11-OXO-DIBENZ[B,E]OXEPIN-2-ACETATE;6,11-dihydro-11-oxo-dibenz[b,e]oxepin-2-acetate,methyl ester(Olopatadine);6,11-Dihydro-11-oxo-dibenz[b,e]oxepin-2-acetic acid methyl ester;Methyl 2-(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetate;6,11-dihydro-11-oxo-dibenz[b,e]oxepin-2-acetate
• CAS NO: 55689-64-0
• Molecular Formula: C₁₇H₁₄O₄
• Molecular Weight: 282.29066
• EINECS: 1312995-182-4
• Product Categories: APIs Intermediate;OLMESARTAN
• Mol File: 55689-64-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 459.8 °C at 760 mmHg
• Flash Point: 205.6 °C
• Appearance: /
• Density: 1.259 g/cm³
• Vapor Pressure: 1.23E-08mmHg at 25°C
• Refractive Index: 1.594
• CAS DataBase Reference: 6,11-dihydro-11-oxo-dibenz[b,e]oxepin-2-acetate,methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 6,11-dihydro-11-oxo-dibenz[b,e]oxepin-2-acetate,methyl ester(55689-64-0)
• EPA Substance Registry System: 6,11-dihydro-11-oxo-dibenz[b,e]oxepin-2-acetate,methyl ester(55689-64-0)

Safety Data

• Hazardous Substances Data: 55689-64-0(Hazardous Substances Data)

Usage

General Description

"6,11-dihydro-11-oxo-dibenz[b,e]oxepin-2-acetate, methyl ester" is a chemical compound that belongs to the class of dibenzoxepins. These are compounds containing a dibenzoxepin moiety, which consists of two benzene rings bonded to each other and to an oxepine. Dibenzoxepins are frequently seen in a variety of pharmaceutical substances and are studied for their various biological activities. "6,11-dihydro-11-oxo-dibenz[b,e]oxepin-2-acetate, methyl ester" specifically, contains an acetate group, an ester group and an oxo group in its structure, but its specific properties and usages are not widely reported in the literature. Like other such complex organic compounds, it could potentially be used in a variety of fields including medicinal chemistry, material science, and synthetic chemistry.

InChI:InChI=1/C17H14O4/c1-20-16(18)9-11-6-7-15-14(8-11)17(19)13-5-3-2-4-12(13)10-21-15/h2-8H,9-10H2,1H3

Upstream product

• 55453-87-7 isoxepac 
• 67-56-1 methanol 

Downstream Products

• 138889-95-9 11-(2-Diethylamino-ethylsulfanyl)-6,11-dihydro-dibenzo[b,e]oxepine-2-carboxylic acid methyl ester 
• 56427-50-0 methyl 6,11-dihydro-11-hydroxydibenz[b,e]oxepin-2-acetate 
• 56427-48-6 methyl 6,11-Dihydro-11-methoxydibenz[b,e]oxepin-2-acetate 
• 123227-54-3 methyl 11-(2-aminoethyl)thio-6,11-dihydrodibenz[b,e]oxepin-2-acetate 
• 123226-65-3 [11-(2-Benzenesulfonylamino-ethylsulfanyl)-6,11-dihydro-dibenzo[b,e]oxepin-2-yl]-acetic acid methyl ester 
• 123226-88-0 sodium 11-[2-[(phenylsulfonyl)amino]ethyl]thio-6,11-dihydrodibenz[b,e]oxepin-2-acetate 
• 105670-45-9 Methyl 11-<2-(dimethylamino)ethyl>thio-6,11-dihydrodibenzoxepin-2-acetate 
• 138890-00-3 11-(2-Diethylamino-ethylsulfanyl)-6,11-dihydro-dibenzo[b,e]oxepine-2-carboxylic acid; hydrochloride 
• 105671-03-2 [11-(2-Dimethylamino-ethylsulfanyl)-6,11-dihydro-dibenzo[b,e]oxepin-2-yl]-acetic acid; hydrochloride 
• 56427-65-7 11-hydroxy-2-(2-hydroxyethyl)-6,11-dihydrodibenz[b,e]oxepin 
• 1569631-86-2 methyl 2-[11-hydroxy-11-(3-hydroxypropyl)-6,11-dihydrodibenzo[b,e]oxepin-2-yl]acetate 
• 1569631-80-6 methyl 2-[4′,5′-dihydro-3′H,6H-spiro(dibenzo[b,e]oxepine-11,2′-furan)-2-yl]acetate 
• 916243-39-5 (Z)-methyl 2-[11-(3-hydroxypropylidene)-6,11-dihydrodibenzo[b,e]oxepin-2-yl]acetate 
• 1569631-79-3 (E)-methyl 2-[11-(3-hydroxypropylidene)-6,11-dihydrodibenzo[b,e]oxepin-2-yl]acetate 

Relevant articles and documents

Preparation method of carboxylic ester compound

The invention relates to a preparation method of a carboxylic ester compound, which comprises the following steps: reacting carboxylic acid with methanol in air under the catalysis of nitrite to obtain an ester compound, the preparation method disclosed by the invention has the advantages of rich raw material sources, cheap and easily available catalyst, mild reaction conditions, simplicity and convenience in operation and the like, a series of fatty carboxylic acids can be modified with high yield, and particularly, the traditional esterification method is generally not suitable for esterification of drug molecules. By utilizing the method, a series of known drug molecules can be modified, so that a shortcut is provided for discovering new drug molecules.

A PROCESS FOR THE SYNTHESIS OF OLOPATADINE

The present invention provides a process for the synthesis of olopatadine. Further, the invention discloses a process that results in improved yield of the desired Z isomer.

TRICYCLIC COMPOUNDS

Novel tricyclic compound represented by formula STR1 possess a TXA. sub.2 biosynthesis inhibiting activity and/or a TXA 2 receptor antagonizing activity, and are expected to have preventive and therapeutic effects on ischemic diseases, cerebro-vascular diseases, etc.