5576-97-6 Usage
Description
4-METHOXY-BETA-NITROSTYRENE, also known as trans-4-Methoxy-β-nitrostyrene, is an organic compound that plays a significant role in various chemical reactions and applications due to its unique molecular structure. It is characterized by the presence of a nitro group and a methoxy group attached to a styrene backbone, which allows it to participate in different chemical processes.
Uses
Used in Pharmaceutical Industry:
4-METHOXY-BETA-NITROSTYRENE is used as a Michael acceptor for the synthesis of proline-based chiral ionic liquid catalysts with two five-membered unsaturated aza-heterocycles. These catalysts are essential in the development of new pharmaceutical compounds and can improve the efficiency and selectivity of various chemical reactions.
Used in Material Science:
In the field of material science, 4-METHOXY-BETA-NITROSTYRENE acts as a guest molecule and forms co-crystal phases with the d-form of robust syndiotactic polystyrene (sPS). This application is crucial for the development of new materials with enhanced properties, such as improved mechanical strength, thermal stability, and chemical resistance.
General Description:
4-METHOXY-BETA-NITROSTYRENE participates in the Michael reaction on carbapenam intermediate, which is a significant chemical process in the synthesis of various pharmaceutical compounds. Its ability to act as a Michael acceptor makes it a valuable component in the development of new drugs and materials.
Check Digit Verification of cas no
The CAS Registry Mumber 5576-97-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,5,7 and 6 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 5576-97:
(6*5)+(5*5)+(4*7)+(3*6)+(2*9)+(1*7)=126
126 % 10 = 6
So 5576-97-6 is a valid CAS Registry Number.
5576-97-6Relevant articles and documents
Metal-free Synthesis of β-Nitrostyrenes via DDQ-Catalyzed Nitration
Min, Sun-Joon,Park, Sangwoon,Yoon, Seungri
, p. 525 - 528 (2021/02/22)
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Metal-Free Deoxygenation of Chiral Nitroalkanes: An Easy Entry to α-Substituted Enantiomerically Enriched Nitriles
Pirola, Margherita,Faverio, Chiara,Orlandi, Manuel,Benaglia, Maurizio
supporting information, p. 10247 - 10250 (2021/06/18)
A metal-free, mild and chemodivergent transformation involving nitroalkanes has been developed. Under optimized reaction conditions, in the presence of trichlorosilane and a tertiary amine, aliphatic nitroalkanes were selectively converted into amines or nitriles. Furthermore, when chiral β-substituted nitro compounds were reacted, the stereochemical integrity of the stereocenter was maintained and α-functionalized nitriles were obtained with no loss of enantiomeric excess. The methodology was successfully applied to the synthesis of chiral β-cyano esters, α-aryl alkylnitriles, and TBS-protected cyanohydrins, including direct precursors of four active pharmaceutical ingredients (ibuprofen, tembamide, aegeline and denopamine).
Dipolar HCP materials as alternatives to DMF solvent for azide-based synthesis
Bai, Rongxian,Gao, Feng,Gu, Yanlong,Li, Minghao
supporting information, p. 7499 - 7505 (2021/10/12)
Hypercrosslinked polymers HCP-DMF and HCP-DMF-SO3H containing abundant and flexible DMF moieties were designed and synthesized. Benefitting from the solvation microenvironment provided by the pseudo-DMF moities, the polar HCPs manifested outstanding performances in the conversions of NaN3 to benzylic azides and 1,2,3-triazoles in EtOH (95%), respectively, avoiding the use of risky DMF and improving the separation processes of the products.