55831-94-2Relevant articles and documents
Promotion of feed efficiency in animals
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, (2008/06/13)
Feed supplements, which increase the dwell time of ingested nutrient matter in the gastrointestinal tract of food producing animals, and which provide for increased digestion and absorption of ingested nutrient matter, are administered to food producing animals to increase feed efficiency.
Method of treating scours
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, (2008/06/13)
Scours in animals, particularly new-born calves, lambs, piglets and foals are treated with a compound containing an effective amount of an antidiarrheal amidinourea.
Antimotility and antisecretory activity of some aryl substituted amidinoureas
Douglas,Diamond,Studt,Mir,Alioto,Auyang,Burns,Cias,Darkes,Dodson,O'Connor,Santora,Tsuei,Zalipsky,Zimmerman
, p. 1435 - 1441 (2007/10/05)
A number of aryl substituted amidinoureas have been prepared and examined for their gastrointestinal spasmolytic, antimotility, antidiarrheal and antisecretory effects. In general, antisecretory and antimotility effects have been found to be associated with each other in these compounds. The structure-activity relationships found show that substitution of the aromatic ring in positions other than 2 and 6 correlates poorly with potency, and potency of such compounds is low. In contrast to this, 2,6-disubstitution confers high potency. The potency of 2,6-disubstituted compounds declines sharply with increasing weight of substitution of the amidinourea chain, with the important exception of the N-alkoxyamidinoureas. Increasing the molecular weight of an N-alkoxy substituent has a much less profound effect than the corresponding increase has in an N-alkyl substituent. High potency in an amidinourea may well be related to low basicity (or a high pK(a) value for its conjugate salt) but there is insufficient data to support this hypothesis fully. The actual tautomeric structure of an amidinourea probably affects its potency and this is discussed briefly.
