5597-50-2

Basic information

• Product Name: Methyl 3-(4-hydroxyphenyl)propionate
• Synonyms: METHYL 3-(4-HYDROXYPHENYL)PROPIONATE;METHYL P-HYDROXYHYDROCINNAMATE;4-hydroxy-benzenepropanoic acid methyl ester;3-(4-HYDROXYPHENYL)PROPIONIC ACID METHYL ESTER;3-(4'-HYDROXYPHENYL)-PROPIONIC ACID-OME;3-(4-HYDROXY-PHENYL)-PROPIONIC ACID-OME;4-hydroxy-benzenepropanoicacimethylester;Hydrocinnamic acid, p-hydroxy-, methyl ester
• CAS NO: 5597-50-2
• Molecular Formula: C₁₀H₁₂O₃
• Molecular Weight: 180.2
• Product Categories: Acids and Derivatives;Alcohols and Derivatives;Aromatic Esters;(intermediate of esmolol);C10 to C11;Carbonyl Compounds;Esters
• Mol File: 5597-50-2.mol
• Article Data: 103

Chemical Properties

• Melting Point: 39-41 °C(lit.)
• Boiling Point: 108 °C11 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: White transparent/Powder
• Density: 1.1272 (rough estimate)
• Vapor Pressure: 1.21E-14mmHg at 25°C
• Refractive Index: 1.5160 (estimate)
• Storage Temp.: 2-8°C
• Solubility: Soluble in chloroform and methanol.
• PKA: 9.89±0.15(Predicted)
• CAS DataBase Reference: Methyl 3-(4-hydroxyphenyl)propionate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 3-(4-hydroxyphenyl)propionate(5597-50-2)
• EPA Substance Registry System: Methyl 3-(4-hydroxyphenyl)propionate(5597-50-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 5597-50-2(Hazardous Substances Data)

Usage

Description

Methyl 3-(4-hydroxyphenyl)propionate is an organic compound that features a methyl ester group attached to a 3-(4-hydroxyphenyl)propanoic acid structure. It is characterized by the presence of a phenolic hydroxyl group and a carboxylate group, which can engage in various chemical reactions and interactions.

Uses

Used in Enzymatic Coupling Applications:
Methyl 3-(4-hydroxyphenyl)propionate is utilized as a coupling agent in the enzymatic coupling of saccharides to proteins. This process is crucial for the synthesis of glycoproteins, which are essential in various biological functions and have potential applications in the pharmaceutical and biotechnology industries. Methyl 3-(4-hydroxyphenyl)propionate aids in the efficient attachment of sugar molecules to protein structures, facilitating the production of desired glycoproteins with specific properties.

InChI:InChI=1/C22H27N3O2S/c1-14-2-4-18(5-3-14)27-12-20-23-21(25-24-20)28-13-19(26)22-9-15-6-16(10-22)8-17(7-15)11-22/h2-5,15-17H,6-13H2,1H3,(H,23,24,25)

Upstream product

• 67-56-1 methanol 
• 501-97-3 4-hydroxyphenylpropionic acid 
• 3943-97-3 methyl 4-hydroxycinnamate 
• 77092-56-9 methyl 3-(p-MEMoxyphenyl)propionate 
• 6386-38-5 methyl 3-(4-hydroxy-3,5-di-tert-butyl)phenylpropanoate 
• 74-88-4 methyl iodide 
• 186581-53-3 diazomethane 
• 195454-08-1 3-[4-({[4-({Acetyl-[2-(4-hydroxy-phenyl)-ethyl]-amino}-methyl)-phenyl]-dimethyl-silanyl}-methoxy)-phenyl]-propionic acid methyl ester 
• 7400-08-0 p-Coumaric Acid 
• 475272-11-8 methyl 3-(4-(((trifluoromethyl)sulfonyl)oxy)phenyl)propionate 
• 77-78-1 dimethyl sulfate 
• 3943-97-3 methyl p-hydroxycinnamate 
• 61240-27-5 3-(4'-hydroxyphenyl)-(Z)-propenoic acid methyl ester 
• 123-08-0 4-hydroxy-benzaldehyde 

Downstream Products

• 23838-70-2 3-(4-hydroxyphenyl)propanoic acid amide 
• 24807-40-7 methyl 3-(4-benzyloxyphenyl)propanoate 
• 70193-47-4 3-{4-[3-(4-Chloro-phenoxy)-2-oxo-propoxy]-phenyl}-propionic acid methyl ester 
• 60377-06-2 3-{4-[3-(4-Chloro-phenoxy)-2-hydroxy-propoxy]-phenyl}-propionic acid methyl ester 
• 60377-36-8 3-{4-[3-(4-Chloro-phenylsulfanyl)-2-hydroxy-propoxy]-phenyl}-propionic acid methyl ester 
• 70192-90-4 3-{4-[3-(4-tert-Butyl-phenoxy)-2-oxo-propoxy]-phenyl}-propionic acid methyl ester 
• 60377-56-2 3-{4-[3-(4-tert-Butyl-phenoxy)-2-hydroxy-propoxy]-phenyl}-propionic acid 
• 155997-93-6 methyl 3-(4-tetrahydropyran-2-yloxyphenyl)propionate 
• 84299-04-7 3-[4-(3-Chloro-4-methoxy-benzyloxy)-phenyl]-propionic acid 
• 62442-94-8 3-(4-Tetradecyloxy-phenyl)-propionic acid methyl ester 
• 77092-56-9 methyl 3-(p-MEMoxyphenyl)propionate 
• 81147-94-6 methyl 3-<4-(2,3-epoxypropoxy)phenyl>propionate 
• 161249-56-5 3-[4-(tert-butyl-dimethyl-silanyloxy)phenyl]propionic acid methyl ester 
• 97387-80-9 1-(3,4-dimethoxy-phenyl)-but-3-en-1-ol 

Relevant articles and documents

Semi-aromatic biobased polyesters derived from lignin and cyclic carbonates

The synthesis of biobased aromatic polyesters from lignin-derived monomers has become well described in the literature, but robust extrusion, thermomechanical, tensile and degradation studies of these materials is lacking. In this work, we have systematically investigated the mechanical and biodegradation properties of semi-aromatic polyesters that can potentially be derived from lignin. AB monomers were synthesized from reduced analogues of coumaric, ferulic, and sinapic acids along with cyclic carbonates, where the synthetic methodology was assessed using E-Factor and EcoScale. Polymerization yielded both semi-crystalline and amorphous polyesters with mechanical properties varying over three orders of magnitude. Detailed characterization revealed a wide array of properties including a highly ductile thermoplastic, a strong and rigid thermoplastic, and an elastomer. Composting biodegradation tests showed both degradable and nondegradable polymers can be achieved in this class. This work demonstrates the versatility of this class of polymers and illustrates their potential to replace non-sustainably derived plastics. This journal is

A 2-formylphenylboronic acid (2FPBA)-maleimide crosslinker: a versatile platform for Cys-peptide-hydrazine conjugation and interplay

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Preparation process of high-purity iprolol hydrochloride

The invention belongs to the technical field of organic chemistry and medical chemistry. In particular, the invention relates to a preparation process of high-purity iprolol hydrochloride. To the preparation process, p-hydroxyphenylpropionic acid and methanol are subjected to esterification reaction under the action of first catalyst, and the p-hydroxyphenylpropionic acid methyl ester and epoxy chloropropane are reacted under the action of second catalyst to obtain 3 - [4 - (2, 3 - epoxypropoxy) phenyl] propanoate, and then, methyl propionate is added in the methyl alcohol solvent in this order to obtain methyl p-hydroxybenzenepropanoic acid methyl ester and then in a methanolic solvent, and then the 3 - preparation 4 - process 2 can 3 - be carried out. The crude hydrochloride and hydrogen chloride is subjected to heating dissolution, activated carbon decoloration, cooling crystallization and centrifugation and drying operation in sequence to obtain final high-purity ilomolol hydrochloride with a total impurity lower than 0.5% and a single unknown single impurity lower than 0.05%.