56004-63-8

Basic information

• Product Name: Methanone, (4-methyl-2-thienyl)phenyl-
• CAS NO: 56004-63-8
• Molecular Formula: C12H10OS
• Molecular Weight: 202.277
• Mol File: 56004-63-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Methanone, (4-methyl-2-thienyl)phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, (4-methyl-2-thienyl)phenyl-(56004-63-8)
• EPA Substance Registry System: Methanone, (4-methyl-2-thienyl)phenyl-(56004-63-8)

Safety Data

• Hazardous Substances Data: 56004-63-8(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 616-44-4 3-Methylthiophene 
• 100-52-7 benzaldehyde 
• 100-47-0 benzonitrile 
• 93-97-0 benzoic acid anhydride 

Relevant articles and documents

Preparation of acylthiophenes by iron(III) chloride catalyzed reactions of tris(2-thienyl)stibanes with acyl chlorides

The reactions of tris(2-thienyl)stibanes with various acyl chlorides, using a catalytic amount of iron(III) chloride, afforded 2-acylthiophenes. Iron(III) chloride is presumed to act as a Lewis acid, and the ipso substituent of each 2-thienyl group of tris(2-thienyl)stibane is replaced with an acyl group. The reaction is highly atom-efficient in that all three thiophene rings of tris(2-thienyl)stibane take part in the reaction. The reaction procedure is so simple that it can also be carried out under solvent-free and aerobic conditions.

Highly selective 5-substitution of 3-methylthiophene via directed lithiation

(Chemical Equation Presented) Lithiation of 3-methylthiophene with lithium 2,2,6,6-tetramethylpiperidide (LiTMP) is highly selective at the 5-position, and reaction with a range of electrophiles gives high yields of the corresponding 2,4-disubstituted thiophenes, even when unhindered electrophiles are used.