56133-86-9

Basic information

• Product Name: 2,5-DICHLOROPHENETHYLAMINE
• Synonyms: 2,5-DICHLOROPHENETHYLAMINE;RARECHEM AN KA 0518;2,5-Dichloro-benzeneethanaMine;2-(2,5-Dichlorophenyl)ethanaMine;Benzeneethanamine,2,5-dichloro-;2,5-Dichlorophenethylamine(WX600231)
• CAS NO: 56133-86-9
• Molecular Formula: C₈H₉Cl₂N
• Molecular Weight: 190.07
• EINECS: 924-454-2
• Mol File: 56133-86-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 264.123 °C at 760 mmHg
• Flash Point: 113.538 °C
• Appearance: /
• Density: 1.269 g/cm³
• Vapor Pressure: 0.01mmHg at 25°C
• Refractive Index: 1.57
• Storage Temp.: 2-8°C(protect from light)
• PKA: 9.29±0.10(Predicted)
• CAS DataBase Reference: 2,5-DICHLOROPHENETHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-DICHLOROPHENETHYLAMINE(56133-86-9)
• EPA Substance Registry System: 2,5-DICHLOROPHENETHYLAMINE(56133-86-9)

Safety Data

• Hazardous Substances Data: 56133-86-9(Hazardous Substances Data)

Usage

General Description

2,5-Dichlorophenethylamine, also known as 2,5-DCPEA, is a chemical compound derived from phenethylamine. It is considered a psychoactive drug with stimulant effects and is classified as a designer drug. 2,5-DCPEA has been researched for its potential use in the treatment of conditions such as depression and anxiety. However, its psychoactive effects and potential for abuse have raised concerns about its safety and legal status. The long-term effects of 2,5-DCPEA on human health are not well understood, and its use is not approved for medical or recreational purposes in many countries.

InChI:InChI=1/C8H9Cl2N/c9-7-1-2-8(10)6(5-7)3-4-11/h1-2,5H,3-4,11H2

Upstream product

• 3218-50-6 2-(2,5-dichlorophenyl)acetonitrile 
• 79-22-1 methyl chloroformate 

Downstream Products

• 107926-71-6 N-<2-(2,5-Dichlor-phenyl)-ethyl>-formamid 
• 52569-11-6 Methyl-2-<2-(2,5-dichlor-phenyl)-ethyl>-amin 

Relevant articles and documents

Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors

A new enhancer of zeste homolog 2 (EZH2) inhibitor series comprising a substituted phenyl ring joined to a dimethylpyridone moiety via an amide linkage has been designed. A preferential amide torsion that improved the binding properties of the compounds was identified for this series via computational analysis. Cyclization of the amide linker resulted in a six-membered lactam analogue, compound 18. This transformation significantly improved the ligand efficiency/potency of the cyclized compound relative to its acyclic analogue. Additional optimization of the lactam-containing EZH2 inhibitors focused on lipophilic efficiency (LipE) improvement, which provided compound 31. Compound 31 displayed improved LipE and on-target potency in both biochemical and cellular readouts relative to compound 18. Inhibitor 31 also displayed robust in vivo antitumor growth activity and dose-dependent de-repression of EZH2 target genes.