56159-22-9

Basic information

• Product Name: 2-phenylfuro[3,2-c]pyridine-3-carbonitrile
• CAS NO: 56159-22-9
• Molecular Formula: C₁₄H₈N₂O
• Molecular Weight: 220.2261
• Mol File: 56159-22-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 436.6°C at 760 mmHg
• Flash Point: 217.9°C
• Density: 1.3g/cm³
• Vapor Pressure: 7.96E-08mmHg at 25°C
• Refractive Index: 1.679
• CAS DataBase Reference: 2-phenylfuro[3,2-c]pyridine-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenylfuro[3,2-c]pyridine-3-carbonitrile(56159-22-9)
• EPA Substance Registry System: 2-phenylfuro[3,2-c]pyridine-3-carbonitrile(56159-22-9)

Safety Data

• Hazardous Substances Data: 56159-22-9(Hazardous Substances Data)

Upstream product

• 1122-96-9 4-methoxypyridine N-oxide 
• 935-02-4 3-Phenyl-2-propynonitrile 
• 15177-57-8 3,5-dicholoropyridine N-oxide 
• 56159-13-8 7-chloro-2-phenyl-furo[3,2-c]pyridine-3-carbonitrile 
• 1121-76-2 4-chloropyridine N-oxide 

Relevant articles and documents

THE REACTION OF 4-CHLOROPYRIDINE 1-OXIDES WITH ACTIVATED ACETYLENES. A CONVENIENT ONE-STEP SYNTHESIS OF FUROPYRIDINES

The reaction of 4-chloro- and 4-pseudohalogeno-pyridine 1-oxides with activated acetylenes (phenylcyanoacetylene, methyl phenylpropiolate, phenylpropiolaldehyde, methyl propiolate, and ethynyl p-tolyl sulphone) gave good yields of substituted furopyridines 7.With 1-phenyl-2-methanesulphonylacetylene under mild conditions the initial -shift product 9 was isolated and converted to 7 with base.The structure of 7 was established unambiguously by using Eu(fod)3-induced NMR shifts.The mechanism of the reaction is discussed briefly and consecutive -shifts are proposed to account for the formation 7.