56159-89-8

Basic information

• Product Name: 2',6'-Difluorophenacyl bromide
• Synonyms: 2',6'-DIFLUOROPHENACYL BROMIDE;2,6-DIFLUOROPHENACYL BROMIDE;2-BROMO-1-(2,6-DIFLUOROPHENYL)ETHANONE;2-BROMO-2',6'-DIFLUOROACETOPHENONE;2'',6''-DIFLUOROPHENACYL BROMIDE, 98% MIN.;2-Bromo-1-(2,6-difluorophenyl)ethanone ,98%;2-Bromo-2',6'-difluoroacetophenone, 2-Bromo-1-(2,6-difluorophenyl)ethan-1-one;2-broMo-1-(2,6-difluorophenyl)ethan-1-one
• CAS NO: 56159-89-8
• Molecular Formula: C₈H₅BrF₂O
• Molecular Weight: 235.03
• EINECS: 200-582-5
• Mol File: 56159-89-8.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 234 °C at 760 mmHg
• Flash Point: 95.3 °C
• Appearance: /
• Density: 1.648g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2',6'-Difluorophenacyl bromide(CAS DataBase Reference)
• NIST Chemistry Reference: 2',6'-Difluorophenacyl bromide(56159-89-8)
• EPA Substance Registry System: 2',6'-Difluorophenacyl bromide(56159-89-8)

Safety Data

• Hazard Codes: C,F
• Hazardous Substances Data: 56159-89-8(Hazardous Substances Data)

Usage

General Description

2',6'-Difluorophenacyl bromide is a chemical compound with the molecular formula C9H7BrF2. It is a derivative of acetophenone, a common building block in organic synthesis. 2',6'-Difluorophenacyl bromide is used as a reagent for the preparation of various organic compounds through bromination and acylation reactions. 2',6'-Difluorophenacyl bromide is a versatile and important intermediate in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. It is known for its strong brominating and acylating properties and is often used in the production of organic molecules with specific functional groups and reactivities.

Upstream product

• 13670-99-0 2,6-difluoroacetophenone 

Downstream Products

• 40017-76-3 3-(2,6-difluorophenyl)-3-oxopropanenitrile 
• 40017-77-4 2-Amino-3-(2,6-difluorbenzoyl)-thiophen 
• 40017-80-9 2-Aminoacetylamino-3-(2,6-difluorbenzoyl)-thiophen 
• 40017-98-9 2-Amino-N-[5-chloro-3-(2,6-difluoro-benzoyl)-thiophen-2-yl]-acetamide 
• 40017-78-5 2-Chloro-N-[3-(2,6-difluoro-benzoyl)-thiophen-2-yl]-acetamide 
• 40017-79-6 N-[3-(2,6-Difluoro-benzoyl)-thiophen-2-yl]-2-iodo-acetamide 
• 40017-97-8 N-[5-Chloro-3-(2,6-difluoro-benzoyl)-thiophen-2-yl]-2-iodo-acetamide 
• 40017-96-7 2-Chloro-N-[5-chloro-3-(2,6-difluoro-benzoyl)-thiophen-2-yl]-acetamide 
• 75473-30-2 N-[3-(2,6-Difluoro-benzoyl)-thiophen-2-yl]-2-({[3-(2,6-difluoro-benzoyl)-thiophen-2-ylcarbamoyl]-methyl}-amino)-acetamide 
• 40017-81-0 5-(2,6-difluoro-phenyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one 
• 40018-02-8 5-(2,6-difluoro-phenyl)-1-methyl-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one 
• 40017-75-2 7-chloro-5-(2,6-difluoro-phenyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one 
• 223784-75-6 4-[4-amino-5-(2,6-difluoro-benzoyl)-thiazol-2-ylamino]-benzenesulfonamide 

Relevant articles and documents

High Chemo-/Stereoselectivity for Synthesis of Polysubstituted Monofluorinated Pyrimidyl Enol Ether Derivatives

A novel intramolecular Smiles rearrangement of α-fluoro-β-keto-pyrimidylsulfones (usually used as a carbon nucleophile) was developed, providing a versatile avenue for synthesis of tri/tetra-substituted monofluorinated pyrimidyl enol ethers. Among these, diverse (Z)-monofluorovinylsulfones and sulfinates were efficiently assembled by adding extra electrophile and fine-tuning reaction conditions. The process is triggered by a keto-enol tautomerism from enol oxyanion to pyrimidine 2-carbon, completely different from the classical carbon nucleophilic addition reaction approach.

Utilization of the 1,2,3,5-thiatriazolidin-3-one 1,1-dioxide scaffold in the design of potential inhibitors of human neutrophil proteinase 3

The S′ subsites of human neutrophil proteinase 3 (Pr 3) were probed by constructing diverse libraries of compounds based on the 1,2,3,5-thiatriazolidin-3-one 1,1-dioxide using combinational and click chemistry methods. The multiple points of diversity embodied in the heterocyclic scaffold render it well-suited to the exploration of the S′ subsites of Pr 3. Molecular modeling studies suggest that further exploration of the S′ subsites of Pr 3 using the aforementioned heterocyclic scaffold may lead to the identification of highly selective, reversible competitive inhibitors of Pr 3.

Antiproliferative 2-(heteroaryl)-aminothiazole compounds and pharmaceutical compositions, and methods for their use

Compounds represented by the Formula (I): are described. The compounds and pharmaceutical compositions containing them may be used in inhibiting and/or modulating protein kinases, in treating or preventing diseases associated with protein kinases, and/or in treating or preventing cellular proliferative diseases.