562074-43-5

Basic information

• Product Name: 2-(BOC-AMINO)-5-PICOLINE
• Synonyms: 2-(BOC-AMINO)-5-PICOLINE;TERT-BUTYL 5-METHYLPYRIDIN-2-YLCARBAMATE;Carbamic acid, (5-methyl-2-pyridinyl)-, 1,1-dimethylethyl ester (9CI);Carbamic acid,N-(5-methyl-2-pyridinyl)-,1,1-dimethylethyl ester
• CAS NO: 562074-43-5
• Molecular Formula: C11H16N2O2
• Molecular Weight: 208.26
• Product Categories: N-BOC
• Mol File: 562074-43-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 273.7 °C at 760 mmHg
• Flash Point: 119.3 °C
• Appearance: /
• Density: 1.108 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(BOC-AMINO)-5-PICOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(BOC-AMINO)-5-PICOLINE(562074-43-5)
• EPA Substance Registry System: 2-(BOC-AMINO)-5-PICOLINE(562074-43-5)

Safety Data

• Hazardous Substances Data: 562074-43-5(Hazardous Substances Data)

Usage

General Description

2-(BOC-AMINO)-5-PICOLINE is a chemical compound that contains a BOC (tert-butyloxycarbonyl) protected amino group and a picoline moiety. The BOC group serves as a protecting group for the amino group, allowing for selective deprotection under specific conditions. The picoline moiety is a heterocyclic aromatic compound that contains a pyridine ring with a methyl group in the 2-position. This chemical is commonly used in organic synthesis, particularly in the preparation of pharmaceuticals and agrochemicals. Its unique structure and reactivity make it a valuable building block for the synthesis of complex molecules.

Upstream product

• 1603-41-4 (5-methyl-pyridin-2-yl)amine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 3510-66-5 2-Bromo-5-methylpyridine 
• 4248-19-5 tert-butyl carbazate 

Downstream Products

• 1197332-75-4 5-[4-(4-methoxy-benzyl)-2,2-dimethyl-piperazin-1-ylmethyl]-pyridin-2-ylamine 
• 1197332-76-5 {5-[4-(4-methoxy-benzyl)-2,2-dimethyl-piperazin-1-ylmethyl]-pyridin-2-yl}-carbamic acid tert-butyl ester 

Relevant articles and documents

COMPOUNDS FOR TREATMENT OF CARDIAC ARRHYTHMIAS AND HEART FAILURE

This disclosure concerns compounds and a method for modulating the activity of calcium ion channels, including Ca2+-induced (or Ca2+-activated) calcium release channels and conformationally coupled calcium release channels such as ryanodine receptors. Some of the compounds have a structure according to formula I, or a stereoisomer, tautomer, hydrate, solvate, prodrug, or pharmaceutically acceptable salt thereof.

Synthesis of 3-Aminoimidazo[1,2-a]pyridines from α-Aminopyridinyl Amides

3-Aminoimidazo[1,2-a]pyridines are rapidly synthesized via a facile and mild cyclodehydration-aromatization reaction starting from readily available amides. The cyclodehydration step is mediated by the activation of N-Boc-protected 2-aminopyridine-containing amides by triflic anhydride (Tf2O) in the presence of 2-methoxypyridine (2-MeO-Py). Subsequently, the addition of K2CO3 in THF ensured a clean deprotection-aromatization sequence to afford the desired heterocycle. A wide variety of functional groups and substitution patterns were tolerated under the optimized procedure, and good to excellent yields were obtained for the fused bicyclic 3-aza-heterocycles. In addition, the reaction was found to be scalable to gram-scale and could be performed with unprotected acyclic amide precursors. We also found that the resulting products were valuable intermediates for both Pd- and Ru-catalyzed C-H arylation reactions, allowing for the elaboration to diversely functionalized building blocks.

IMIDAZOLE DERIVATIVES USED AS TAFIA INHIBITORS

The invention relates to compounds of formula (I), which are inhibitors of the activated thrombin-activatable fibrinolysis inhibitor. The compounds of formula (I) are suited for producing medicaments for the prevention and treatment of diseases accompanied by thromboses, embolisms, hypercoagulability or fibrotic changes.