56239-26-0

Basic information

• Product Name: 4-aminocyclohexan-1-ol
• Synonyms: 4-aminocyclohexan-1-ol;CIS-4-AMINOCYCLOHEXANOL HCL;cis-4-HydroxycyclohexylaMine Hydrochloride;Cyclohexanol, 4-aMino-,hydrochloride (1:1), cis-;CIS-4-aMinocyclohexan-1-ol hydrochloride;rac-cis-4-AMinocyclohexanol Hydrochloride;(1s,4s)-4-aMinocyclohexanol hydrochloride;Cis-4-aMinocycloride
• CAS NO: 56239-26-0
• Molecular Formula: C₆H₁₃NO*ClH
• Molecular Weight: 151.63
• EINECS: 1308068-626-2
• Product Categories: Chiral Reagents;Intermediates
• Mol File: 56239-26-0.mol
• Article Data: 1

Chemical Properties

• Melting Point: 193-200℃
• Boiling Point: 241.2 °C at 760 mmHg
• Flash Point: 99.7 °C
• Appearance: /Solid
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: 4-aminocyclohexan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-aminocyclohexan-1-ol(56239-26-0)
• EPA Substance Registry System: 4-aminocyclohexan-1-ol(56239-26-0)

Safety Data

• Hazard Codes: Xi:
• Statements: 36/37/38:
• Safety Statements: R26;R37/39:
• Hazardous Substances Data: 56239-26-0(Hazardous Substances Data)

Usage

Description

4-aminocyclohexan-1-ol is an organic compound with the molecular formula C6H11NO. It is a cyclohexanol derivative featuring an amino group attached to the fourth carbon atom of the cyclohexane ring. This structural characteristic endows 4-aminocyclohexan-1-ol with unique chemical and biological properties, making it a versatile building block in the synthesis of various pharmaceuticals and biologically active molecules.

Uses

Used in Pharmaceutical Industry:
4-aminocyclohexan-1-ol is used as a key intermediate in the synthesis of potential hypertensive agents. Its unique structure allows for the development of compounds that can effectively manage blood pressure levels, providing a valuable contribution to the treatment of hypertension and related cardiovascular conditions.
Additionally, 4-aminocyclohexan-1-ol serves as a building block for the preparation of other biologically active compounds. Its versatile chemical properties enable the creation of a wide range of molecules with potential applications in various therapeutic areas, including but not limited to, pain management, inflammation, and neurological disorders.

Upstream product

• 56239-25-9 (+/-)-2-Oxa-3-azabicyclo[2.2.2]oct-5-ene hydrochloride 

Downstream Products

• 1228947-14-5 (1r,4r)-4-(morpholin-4-yl)cyclohexan-1-ol 
• 1377698-66-2 tert-butyl 3-(5-chloro-2-((1s,4s)-4-hydroxycyclohexylamino)pyridin-4-yl)phenyl((tetrahydro-2H-pyran-4-yl)methyl)carbamate 
• 1374215-13-0 ethyl 6-chloro-4-(((1s,4s)-4-hydroxycyclohexyl)amino)nicotinate 
• 1374211-56-9 6-(4-(4-acetylpiperazin-1-yl)phenylamino)-4-((1s,4s)-4-hydroxycyclohexylamino)nicotinamide 

Relevant articles and documents

CYCLOHEXYLAMIN ISOQUINOLONE DERIVATIVES AS RHO-KINASE INHIBITORS

The invention relates to 6-cyclohexylamine-substituted isoquinolone derivatives of the formula (I) or isoquinoline derivatives of the formula (I’) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.