562817-60-1

Basic information

• Product Name: 1-Piperidinecarboxylic acid, 3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenyl-, 1,1-dimethylethyl ester, (2S,3S)-
• CAS NO: 562817-60-1
• Molecular Formula: C25H27F6NO3
• Molecular Weight: 503.485
• Mol File: 562817-60-1.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: 1-Piperidinecarboxylic acid, 3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenyl-, 1,1-dimethylethyl ester, (2S,3S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinecarboxylic acid, 3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenyl-, 1,1-dimethylethyl ester, (2S,3S)-(562817-60-1)
• EPA Substance Registry System: 1-Piperidinecarboxylic acid, 3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenyl-, 1,1-dimethylethyl ester, (2S,3S)-(562817-60-1)

Safety Data

• Hazardous Substances Data: 562817-60-1(Hazardous Substances Data)

Upstream product

• 1609543-92-1 (2R,3S)-3-azido-2-((tert-butyldimethylsilyl)oxy)-3-phenylpropan-1-ol 
• 1609543-93-2 (2R,3S)-3-azido-2-((tert-butyldimethylsilyl)oxy)-3-phenylpropanal 
• 1609543-94-3 ethyl (4S,5S,E)-5-azido-4-((tert-butyldimethylsilyl)oxy)-5-phenylpent-2-enoate 
• 1609543-96-5 (5S,6S)-5-((tert-butyldimethylsilyl)oxy)-6-phenylpiperidin-2-one 
• 98-80-6 phenylboronic acid 
• 178918-29-1 furan-2-ylmethylcarbamic acid tert-butyl ester 
• 250589-63-0 (2S,3R)-tert-butyl 3-hydroxy-2-phenylpiperidine-1-carboxylic acid 
• 100-58-3 phenylmagnesium bromide 

Downstream Products

• 159249-47-5 tert-butyl (2S,3S)-3-hydroxy-2-phenylpiperidine-1-carboxylate 
• 191669-62-2 (S)-tert-butyl 3-carbonyl-2-phenylpiperidine-1-carboxylic acid 
• 148687-76-7 (2S,3S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenylpiperidine hydrochloride 
• 148700-85-0 L 733060 

Relevant articles and documents

Synthesis of 2-Arylpiperidines via pd-catalyzed arylation of aza-Achmatowicz rearrangement products with arylboronic acids

The first Pd-catalyzed arylation of aza-Achmatowicz rearrangement products with arylboronic acids is achieved, providing versatile 2-Aryldihydropyridinones for facile synthesis of highly functionalized 2-Arylpiperidines. Key to this arylation is the use of non-phosphine-ligand palladium precatalyst. The substrate scope is demonstrated with >26 examples, and the utility of 2-Aryldihydropyridinones is illustrated by the synthesis of a small collection of 2-Arylpiperidines with substituents or functional groups at any carbon (C2-C6) as well as two NK1 receptor antagonists (+)-CP-999,94 and (+)-L-733,060.

A Concise Enantioselective Synthesis of (+)-L-733,060 and (+)-T-2328 via Sequential Proline Catalysis

A new, sequential proline-catalyzed approach to the synthesis of (+)-L-733,060 and (+)-T-2328 in high optical purity (93% ee) is described starting from phenyl N-Boc imine. The strategy involves proline-catalyzed Mannich reaction of an arylimine with acet

Efficient, stereodivergent access to 3-piperidinols by traceless P(OEt)3 cyclodehydration

A stereodivergent and highly diastereoselective (dr up to >19:1 for both isomers), step economic (5-6 steps), and scalable synthesis (up to 14 g) of cis- and trans-2-substituted 3-piperidinols, the core motif of numerous bioactive compounds, providing efficient access to the NK-1 inhibitor L-733,060 is presented. Additionally, a "traceless" (referring to the simplified byproduct separation) cyclodehydration realizing simple P(OEt)3 as a substitute for PPh3 is developed.