56426-41-6

Basic information

• Product Name: 1H-Pyrazole, 5-methyl-3-phenyl-
• CAS NO: 56426-41-6
• Molecular Formula: C10H10N2
• Molecular Weight: 158.203
• Mol File: 56426-41-6.mol
• Article Data: 38

Chemical Properties

• CAS DataBase Reference: 1H-Pyrazole, 5-methyl-3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole, 5-methyl-3-phenyl-(56426-41-6)
• EPA Substance Registry System: 1H-Pyrazole, 5-methyl-3-phenyl-(56426-41-6)

Safety Data

• Hazardous Substances Data: 56426-41-6(Hazardous Substances Data)

Upstream product

• 82755-29-1 5-Methyl-3-phenyl-3,4-dihydro-2H-pyrazol-3-ol 
• 76923-16-5 ethyl 3-methyl-5-phenyl-1H-pyrazole-4-carboxylate 
• 4426-72-6 hydrazine carboxamide 
• 93-91-4 1-phenylbutan-1,3-dione 
• 10244-75-4 1-phenyl-butane-1,3-dione-3-semicarbazone 
• 861598-67-6 4-dipropylamino-4-phenyl-but-3-en-2-one 
• 939-03-7 3-methyl-5-phenyl-4,5-dihydro-1H-pyrazole 
• 1600-27-7 mercury(II) diacetate 
• 64-19-7 acetic acid 
• 563-41-7 semicarbazide hydrochloride 
• 69626-39-7 1-phenylbuta-2,3-dien-1-one 
• 98-86-2 acetophenone 
• 13808-66-7 4-bromo-3-methyl-5-phenyl-1H-pyrazole 
• 536-74-3 phenylacetylene 

Downstream Products

• 10250-60-9 1,5-dimethyl-3-phenyl-1H-pyrazole 
• 10250-58-5 1,3-dimethyl-5-phenyl-1H-pyrazole 
• 851427-81-1 1-ethyl-5-methyl-3-phenyl-1H-pyrazole 
• 155688-81-6 1-Propionyl-5-methyl-3-phenyl-pyrazol 
• 87929-19-9 1-ethoxycarbonyl-3-phenyl-5-methyl-pyrazole 
• 51108-55-5 methyl 5-methyl-3-phenylpyrazole-1-carboxylate 
• 94487-88-4 3-methyl-5-(4-nitrophenyl)pyrazole 
• 119416-32-9 3-methyl-4-nitro-5-(4-nitro-phenyl)-1⁽²⁾H-pyrazole 
• 71549-29-6 4-chloro-3-methyl-5-phenyl-1⁽²⁾H-pyrazole 
• 13808-66-7 4-bromo-3-methyl-5-phenyl-1H-pyrazole 
• 73882-46-9 1-Butyl-3-methyl-5-phenyl-1H-pyrazole 
• 77523-90-1 3-Methyl-5-phenyl-pyrazole-1-carboxylic acid propylamide 
• 77523-83-2 3-Methyl-5-phenyl-pyrazole-1-carbothioic acid ethylamide 
• 155688-79-2 3-methyl-5-phenyl-1-propionylpyrazole 

Relevant articles and documents

More than steric effects: Unlocking the coordination chemistry of barium pyrazolates

To further our understanding of the coordination chemistry of the heavy alkaline earth metals, we here report on a family of barium pyrazolates bearing various substitution patterns that illustrate the delicate balance between ligand bulk, donor size, sto

COMPOUNDS WITH COPPER- OR ZINC-ACTIVATED TOXICITY AGAINST MICROBIAL INFECTION

Heterocyclic compounds with a novel pyrazole thioamide-based NNSN structural motif, having highly effective zinc- or copper-activated toxicity against microbial infections at micromolar or nanomolar minimum inhibitory concentrations (MIC), and methods of making and using same.

Fragmenlt Recombination Design, Synthesis, and Safener Activity of Novel Ester-Substituted Pyrazole Derivatives

Fenoxaprop-p-ethyl (FE), a type of acetyl-CoA carboxylase (ACCase) inhibitor, has been extensively applied to a variety of crop plants. It can cause damage to wheat (Triticum aestivum) even resulting in the death of the crop. On the prerequisite of not reducing herbicidal efficiency on target weed species, herbicide safeners selectively protect crops from herbicide injury. Based on fragment splicing, a series of novel substituted pyrazole derivatives was designed to ultimately address the phytotoxicity to wheat caused by FE. The title compounds were synthesized in a one-pot way and characterized via infrared spectroscopy, 1H nuclear magnetic resonance, 13C nuclear magnetic resonance, and high-resolution mass spectrometry. The bioactivity assay proved that the FE phytotoxicity to wheat could be reduced by most of the title compounds. The molecular docking model indicated that compound IV-21 prevented fenoxaprop acid (FA) from reaching or acting with ACCase. The absorption, distribution, metabolism, excretion, and toxicity predictions demonstrated that compound IV-21 exhibited superior pharmacokinetic properties to the commercialized safener mefenpyr-diethyl. The current work revealed that a series of newly substituted pyrazole derivatives presented strong herbicide safener activity in wheat. This may serve as a potential candidate structure to contribute to the further protection of wheat from herbicide injury.

Monohydrochloride Assisted Synthesis of Functionalized Isoxazoles and Pyrazoles from Allenic Ketones: First Synthesis of (Z)-2-Methyl-7H-benzo[b]pyrazolo[5,1-d][1,5]oxazocines

A facile hydrochloride promoted regioselective synthesis of isoxazoles and pyrazoles from 1,2-allenic ketones is reported. The reaction has been scaled up to gram scale. A direct 8-endo dig ring annulations towards the first synthesis of (Z)-2-methyl-7H-b