56464-72-3

Basic information

• Product Name: 2-amino-2-(p-chlorophenyl)acetonitrile
• Synonyms: 2-amino-2-(p-chlorophenyl)acetonitrile
• CAS NO: 56464-72-3
• Molecular Weight: 166.61
• Mol File: 56464-72-3.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 2-amino-2-(p-chlorophenyl)acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-2-(p-chlorophenyl)acetonitrile(56464-72-3)
• EPA Substance Registry System: 2-amino-2-(p-chlorophenyl)acetonitrile(56464-72-3)

Safety Data

• Hazardous Substances Data: 56464-72-3(Hazardous Substances Data)

Usage

General Description

2-amino-2-(p-chlorophenyl)acetonitrile is a chemical compound with the molecular formula C8H8ClN. It is a white to off-white crystalline solid and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 2-amino-2-(p-chlorophenyl)acetonitrile is also known by its IUPAC name 2-amino-2-(4-chlorophenyl)acetonitrile and is often used as a building block for the production of various biologically active compounds. It has a molecular weight of 151.61 g/mol and is primarily used in research and development processes for the pharmaceutical and agricultural industries. Additionally, it is important to handle this compound with care and follow proper safety guidelines due to its potential health hazards if not used properly.

Upstream product

• 773837-37-9 sodium cyanide 
• 104-88-1 4-chlorobenzaldehyde 
• 7677-24-9 trimethylsilyl cyanide 
• 143-33-9 sodium cyanide 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 151-50-8 potassium cyanide 

Downstream Products

• 56463-73-1 3-acetyl-4-amino-5-(4-chlorophenyl)-2-methylpyrrole 
• 43189-37-3 (R)-2-amino-2-(4-chlorophenyl)acetic acid 
• 1143533-84-9 tert-butyl 4-(((4-chlorophenyl)cyano)methylcarbamoyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-ylcarbamate 
• 49704-71-4 DL-4-chlorophenylglycine nitrile hydrochloride 
• 110088-02-3 [4-Carboxymethyl-2-(4-chloro-phenyl)-6-oxo-piperazin-1-yl]-acetic acid 
• 110087-95-1 N-[2-Acetylamino-1-(4-chloro-phenyl)-ethyl]-acetamide 
• 69810-94-2 1-(4-chlorophenyl)ethane-1,2-diamine 
• 67336-19-0 (S)-2-amino-2-(4-chlorophenyl)acetic acid 
• 110087-91-7 N-[(4-Chloro-phenyl)-cyano-methyl]-acetamide 
• 92303-74-7 4-chloro-(RS)-phenylglycinamide hydrochloride 
• 102333-75-5 2-amino-2-(4-chlorophenyl)acetamide 

Relevant articles and documents

Facile Access to 1,4-Disubstituted Pyrrolo[1,2- a ]pyrazines from α-Aminoacetonitriles

An efficient and practical synthetic protocol for the synthesis of 1,4-disubstituted pyrrolo[1,2- a ]pyrazine derivatives is described that originates from α-substituted pyrroloacetonitriles which, in turn, are readily available from aryl and alkyl aldehydes. The α-pyrroloacetonitriles were subjected to a Friedel-Crafts acylation with methyl chlorooxoacetate followed by reduction of the nitrile group under Pd-catalyzed hydrogenation conditions and finally aromatization with DDQ leading to the desired pyrrolo[1,2- a ]pyrazine derivatives. This method was generalized and successfully applied to various aryl, heteroaryl, and alkyl substrates. The developed protocol provides direct and convenient access to 1,4-disubstituted ring systems in moderate to good overall yields (51-68percent) without the need for purification of the intermediates. Further functionalization via the stepwise halogenation (bromination, iodination) and nitration was also demonstrated. In addition, the potential of the ester functionality for elaboration was demonstrated by manipulating into heterocyclic ring systems, exemplified by conversion into benzoxazole derivatives.

Gold-catalyzed [3+2]-annulations of α-aryl diazonitriles with ynamides and allenamides to yield 1-amino-1H-indenes

Gold-catalyzed [3+2]-annulations of α-aryl diazonitriles with ynamides and allenamides yield 1-amino-1H-indenes in two distinct pathways; the success of these annulations relies on the high electrophilicity of α-cyano arylgold carbenes to activate an ionic pathway.

AMIDES AND METHOD FOR PLANT DISEASE CONTROL WITH THE SAME

N-(α-cyanobenzyl)amide compounds represented by the formula (1): wherein R1 represents a hydrogen atom; a halogen atom; a C1-C6 alkyl group optionally substituted with a halogen atom or the like; or the like, R2 represents a hydrogen atom, a halogen atom, a C1-C6 alkyl group or the like, R3 represents a hydrogen atom or the like, R4 represents a C1-C4 alkyl group, a C3-C4 alkenyl group or the like, R5 represents a C1-C4 alkyl group, a C3-C4 alkenyl group, or the like, R6 represents a hydrogen atom or the like, R7 represents a hydrogen atom or the like, R8 represents a hydrogen atom or the like, R9 represents a hydrogen atom or the like, R10 represents a hydrogen atom or the like, R11 represents a hydrogen atom or the like, and R12 represents a hydrogen atom or the like, have excellent control activities against plant diseases.