5653-88-3Relevant articles and documents
Preparation method of mitiglinide calcium
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Paragraph 0054-0055; 0066-0067, (2018/05/07)
The invention relates to a preparation method of mitiglinide calcium, which includes steps of step 1, synthesis of benzal butanedioic acid; step 2, synthesis of benzylsuccinic acid; step 3, synthesisof (S)-benzylsuccinic acid (R)-alpha- phenylethylamine; step 4, synthesis of (S)-benzylsuccinic acid; step 5, synthesis of 2S-dihydro-isoindole indolebutyric acid; step 6, synthesis of crude product of mitiglinide calcium; step 7, refining of mitiglinide calcium.
Evaluation of a series of 2-napthamide derivatives as inhibitors of the drug efflux pump AcrB for the reversal of antimicrobial resistance
Wang, Yinhu,Mowla, Rumana,Guo, Liwei,Ogunniyi, Abiodun D.,Rahman, Taufiq,De Barros Lopes, Miguel A.,Ma, Shutao,Venter, Henrietta
supporting information, p. 733 - 739 (2017/02/10)
Drug efflux pumps confer multidrug resistance to dangerous pathogens which makes these pumps important drug targets. We have synthesised a novel series of compounds based on a 2-naphthamide pharmacore aimed at inhibiting the efflux pumps from Gram-negativ
Triflic Acid Mediated Cyclization of Unsymmetrical N -Phenethyl- and N -(3-Indolylethyl)succinimides: Regio- and Diastereoselective Synthesis of Substituted Pyrroloisoquinolinones and Indolizino-indolones
Selvakumar, Jayaraman,Mangalaraj, Selvaraj,Achari, Kamsali Murali Mohan,Mukund, Krishna,Ramanathan, Chinnasamy Ramaraj
supporting information, p. 1053 - 1064 (2017/02/24)
The regio and diastereoselective synthesis of 1 or 2 alkyl-substituted pyrroloisoquinolinones and indolizinoindolones by triflic acid mediated cyclization via an electrophilic activation of unsymmetrical succinimide carbonyl groups followed by the reducti