56583-58-5

Basic information

• Product Name: N-T-BOC-D-3-(2-NAPHTHYL)ALANINE
• Synonyms: NALPHA-tert-Butoxycarbonyl-3-(2-naphthyl)-D-alanine
• CAS NO: 56583-58-5
• Molecular Formula: C₁₈H₂₁NO₄
• Molecular Weight: 315.36
• Product Categories: A - H;Amino Acids;Modified Amino Acids
• Mol File: 56583-58-5.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 512.2oC at 760 mmHg
• Flash Point: 263.6oC
• Appearance: /
• Density: 1.2 g/cm3
• Vapor Pressure: 2.58E-11mmHg at 25°C
• Storage Temp.: −20°C
• CAS DataBase Reference: N-T-BOC-D-3-(2-NAPHTHYL)ALANINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-T-BOC-D-3-(2-NAPHTHYL)ALANINE(56583-58-5)
• EPA Substance Registry System: N-T-BOC-D-3-(2-NAPHTHYL)ALANINE(56583-58-5)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 56583-58-5(Hazardous Substances Data)

Usage

General Description

N-T-BOC-D-3-(2-NAPHTHYL)ALANINE is a chemical compound with the molecular formula C22H25NO4. It is commonly used as a chiral building block in the synthesis of pharmaceuticals and other biologically active molecules. The compound contains a BOC (tert-butoxycarbonyl) protecting group, which allows for controlled release of its functional groups in chemical reactions. N-T-BOC-D-3-(2-NAPHTHYL)ALANINE is an important tool in the field of organic chemistry, particularly in the development of new drugs and compounds.

InChI:InChI=1/C18H21NO4/c1-18(2,3)23-17(22)19-15(16(20)21)11-12-8-9-13-6-4-5-7-14(13)10-12/h4-10,15H,11H2,1-3H3,(H,19,22)(H,20,21)/p-1/t15-/m1/s1

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 6960-34-5 L-3-(2-naphthyl)alanine 
• 37447-33-9 acetylamino-[2]naphthylmethyl-malonic acid diethyl ester 
• 37439-99-9 (S)-N-acetyl-3-(2-naphthyl)alanine 
• 136015-50-4 2-Acetylamino-2-naphthalen-2-ylmethyl-malonic acid monoethyl ester 
• 172214-89-0 2-Acetylamino-3-naphthalen-2-yl-propionic acid ethyl ester 
• 939-26-4 2-bromomethylnaphthyl bromide 
• 74651-77-7 2-(tert-butoxycarbonyloxyimino)-2-phenylacetonitrile 
• 1393112-51-0 (RS)-S-ethyl 2-(tert-butoxycarbonylamino)-3-(naphthalen-2-yl)propanethioate 
• 1393112-55-4 (S)-S-ethyl 2-(tert-butoxycarbonylamino)-3-(naphthalen-2-yl)propanethioate 
• 58438-04-3 N-tert-butoxycarbonyl-3-(2-naphthyl)-alanine 
• 636572-72-0 C₂₃H₂₉NO₆ 
• 63024-44-2 2-Amino-3-naphthalen-2-yl-propionic acid; hydrochloride 
• 143218-07-9 ethyl 2-acetylamino-2-cyano-3-(naphthalen-2-yl)propanoate 

Downstream Products

• 145232-20-8 Boc-2-Nal-OSu 
• 1026485-87-9 {(S)-1-[(S)-1-((S)-1-Benzyl-3-chloro-2-oxo-propylcarbamoyl)-2-carbamoyl-ethylcarbamoyl]-2-naphthalen-2-yl-ethyl}-carbamic acid tert-butyl ester 
• 136794-01-9 (S)-3-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-naphthalen-2-yl-propionylamino)-hexanoylamino]-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid benzyl ester 
• 139428-95-8 (S)-2-(1,1-dimethyl-ethyloxycarbonyl)amino-3(2-naphthyl)propan-1-ol 
• 103144-01-0 [1-(2-Benzoyl-4-chloro-phenylcarbamoyl)-2-naphthalen-2-yl-ethyl]-carbamic acid tert-butyl ester 
• 636572-72-0 C₂₃H₂₉NO₆ 
• 1027652-85-2 3,5-dimethylbenzyl (2S)-2-t-butyloxycarbonylamino-3-(2-naphthyl)propionate 
• 138449-24-8 BOC-(S)-3-(2-naphthyl)alanyl-N-benzyl-N-methylamide 
• 190908-91-9 (1-(S)-methylcarbamoyl-2-naphthalen-2-yl-ethyl)-carbamic acid tert-butyl ester 
• 195718-11-7 {(S)-1-[4-(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-phenylcarbamoyl]-2-naphthalen-2-yl-ethyl}-carbamic acid tert-butyl ester 
• 200864-78-4 [(S)-1-(3-Morpholin-4-yl-propylcarbamoyl)-2-naphthalen-2-yl-ethyl]-carbamic acid tert-butyl ester 
• 200864-79-5 Boc-D-β-(2-Naphthyl)alanine 2-(4-Hydroxyphenyl)ethylamide 
• 92635-09-1 [(S)-2-Naphthalen-2-yl-1-((S)-1-phenyl-ethylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester 
• 138449-28-2 (2S)-2-[(tert-butoxy)carbonylamino]-3-(2-naphthyl)-N-benzylpropanamide 

Relevant articles and documents

ARYLPYRROLIDINE DICARBOXYLIC ACID AMIDE DERIVATIVE

PROBLEM TO BE SOLVED: To provide a pyrrolidine derivative capable of catalyzing an asymmetric oxidation reaction of an alkene compound. SOLUTION: There is provided an arylpyrrolidine dicarboxylic acid amide derivative exemplified by cat.A in the following formula. There is provided an asymmetric oxidation catalyst having optical purity of 50%. There is provided a manufacturing method of an optically active epoxy compound including contacting the compound with an alkene derivative in addition to a co-oxidant. There is provided a manufacturing method of an optically active epoxy compound, in which the alkene derivative is a substituted alkene derivative having a functional group containing N or O at 3 position of a double bond. SELECTED DRAWING: None COPYRIGHT: (C)2019,JPOandINPIT

Naphthyl-l-α-amino acids via chemo-enzymatic dynamic kinetic resolution

A double catalyst system (protease + base) was applied to the dynamic kinetic resolution (DKR) of isomeric 1- and 2-α-naphthyl-glycines and -alanines exploiting the in situ racemization of their thioesters. Due to the different C-acidity of the two sets of compounds, different experimental conditions have been devised to perform the simultaneous resolution/racemization process. In all cases, the racemic N-Boc-thioesters were converted into the aminoacids with an l-configuration almost quantitatively and with complete enantioselectivity. 2012 Elsevier Ltd.

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