566205-01-4

Basic information

• Product Name: 3,5-DIBROMO-6-CHLOROPYRAZIN-2-AMINE
• Synonyms: 3,5-DIBROMO-6-CHLOROPYRAZIN-2-AMINE;3,5-DIBROMO-6-CHLORO-2-PYRAZINAMINE;2-Amino-3,5-dibromo-6-chloropyrazine
• CAS NO: 566205-01-4
• Molecular Formula: C₄H₂Br₂ClN₃
• Molecular Weight: 287.35
• Mol File: 566205-01-4.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 324°C at 760 mmHg
• Flash Point: 149.7°C
• Appearance: /
• Density: 2.345g/cm³
• Vapor Pressure: 0.000253mmHg at 25°C
• Refractive Index: 1.692
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: -1.51±0.10(Predicted)
• CAS DataBase Reference: 3,5-DIBROMO-6-CHLOROPYRAZIN-2-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-DIBROMO-6-CHLOROPYRAZIN-2-AMINE(566205-01-4)
• EPA Substance Registry System: 3,5-DIBROMO-6-CHLOROPYRAZIN-2-AMINE(566205-01-4)

Safety Data

• Hazardous Substances Data: 566205-01-4(Hazardous Substances Data)

Usage

General Description

3,5-Dibromo-6-chloropyrazin-2-amine is a synthetic chemical compound. It's a substance mostly used in the pharmaceutical industry to create various drugs due to its pyrazine structure - a class of aromatic organic compounds with the molecular formula C4H4N2. It comprises a mixture of bromine, chlorine, nitrogen, and amine groups, making it a versatile compound for creating complex chemical structures. Although generally safe to use under controlled conditions, this chemical requires safe handling as it may pose dangers if directly exposed to living organisms without proper safety measures. Information on toxicity, exposure risks or environmental impact largely depends on its final use.

InChI:InChI=1/C4H2Br2ClN3/c5-1-3(7)10-4(8)2(6)9-1/h(H2,8,10)

Upstream product

• 33332-28-4 2-amino-6-chloropyrazine 

Downstream Products

• 1397691-95-0 2-amino-3-benzyl-5-bromo-6-chloropyrazine 
• 1427500-74-0 N-phenyl-2-amino-6-bromo-5-chlorothiazolo[4,5-b]pyrazine 
• 1427500-76-2 N-(3-fluorophenyl)-2-amino-6-bromo-5-chlorothiazolo[4,5-b]pyrazine 
• 1427500-75-1 N-2-amino-6-bromo-5-chloro-(2,4-dimethoxybenzyl)thiazolo[4,5-b]pyrazine 

Relevant articles and documents

Synthesis, Structure-Activity Relationships, and Antiviral Activity of Allosteric Inhibitors of Flavivirus NS2B-NS3 Protease

Flaviviruses, including Zika, dengue, and West Nile viruses, are important human pathogens. The highly conserved NS2B-NS3 protease of Flavivirus is essential for viral replication and therefore a promising drug target. Through compound screening, followed by medicinal chemistry studies, a novel series of 2,5,6-trisubstituted pyrazine compounds are found to be potent, allosteric inhibitors of Zika virus protease (ZVpro) with IC50 values as low as 130 nM. Their structure-activity relationships are discussed. The ZVpro inhibitors also inhibit homologous proteases of dengue and West Nile viruses, and their inhibitory activities are correlated. The most potent compounds 47 and 103 potently inhibited Zika virus replication in cells with EC68 values of 300-600 nM and in a mouse model of Zika infection. These compounds represent novel pharmacological leads for drug development against Flavivirus infections.

Concise Synthesis of v-Coelenterazines

A novel synthetic method for v-coelenterazine (v-CTZ), which is a vinylene-bridged analog of native CTZ with a large red-shifted luminescence property, is described. The synthesis was achieved in a concise way through the use of three sequential cross-cou

PYRROLO[2,3-B]PYRAZINES AS SYK INHIBITORS

The present invention relates to the use of novel pyrrolo[2,3- b]]pyrazines wherein all variable substituents are defined as described herein, which are SYK inhibitors and are useful for the treatment of auto-immune and inflammatory diseases.