56621-53-5Relevant articles and documents
Synthesis and biological evaluation of 1,3,4-triaryl-3-pyrrolin-2-ones, a new class of selective cyclooxygenase-2 inhibitors
Bosch, Joan,Roca, Tomas,Catena, Juan-Lorenzo,Llorens, Oriol,Perez, Juan-Jesus,Lagunas, Carmen,Fernandez, Andres G.,Miquel, Ignasi,Fernandez-Serrat, Ana,Farrerons, Carles
, p. 1745 - 1748 (2007/10/03)
The synthesis and structure-activity relationships (SAR) of a series of novel selective COX-2 inhibitors are reported. The results show that some of the 1,3,4-triaryl-3-pyrrolin-2-ones 1 are more potent as COX-2 inhibitors than celecoxib, and that lactam