56637-45-7Relevant articles and documents
Mild Deprotection of Dithioacetals by TMSCl/NaI Association in CH3CN
Yao, Yunxin,Zhao, Guangkuan,Hamze, Abdallah,Alami, Mouad,Provot, Olivier
, p. 5775 - 5779 (2020/08/17)
A mild process using a combination of TMSCl and NaI in acetonitrile is used to regenerate carbonyl compounds from a variety of dithiane and dithiolane derivatives. This easy to handle and inexpensive protocol is also efficient to deprotect oxygenated and mixed acetals as 1,3-dioxanes, 1,3-dioxolanes and 1,3-oxathianes quantitatively. As a possible extension of this method, it was also shown that nitrogenated substrates such as hydrazones, N-tosylhydrazones, and ketimines reacted well under these conditions to give the expected ketones in high yields. The methodology proposed herein is a good alternative to the existing methods since it does not use metals, oxidants, reducing agents, acidic or basic media, and keto-products were obtained in high to excellent yields.
A substituted -1,3-dithiane-preparation method of compound
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Paragraph 0044-0048, (2017/01/31)
The invention discloses a method for preparing substituted-1,3-dithiane compounds. The method comprises the following steps: 1. with 1,2-dichloroethane or dichloromethane as a solvent, stirring to react 2-chlor-1,3-dithiane with alkynes with a general formula I for 1-24 hours at a temperature condition of 45-80 DEG C in the presence of an acid medium and alcoholic compounds; 2. removing the solvent in the reaction system by rotary evaporation after the reaction, and separating and purifying the residues by column chromatography to obtain substituted-1,3-dithiane compounds with a general formula II. According to the method disclosed by the invention, the 2-chlor-1,3-dithiane directly reacts with different types of alkynes, thereby not only avoiding the defects of foul smell, strong volatility and toxicity when 1,3-propanedithiol is used, but also being safe in operation and environmental friendly, and the method has the advantages of mild reaction conditions, simple operation, high yield, etc.
Chemoselective dithioacetalization and oxathioacetalization of carbonyl compounds using alumina sulfuric acid as catalyst
Shaterian, Hamid Reza,Hosseinian, Asghar,Ghashang, Majid
experimental part, p. 4097 - 4106 (2009/04/11)
Carbonyl compounds have been successfully converted into their corresponding dithiolane, dithiane, and oxathiolane derivatives using a catalytic amount of alumina sulfuric acid (Al2O3-SO3H) with excellent yields at room temperature in short reaction times under mild conditions. This simple method is a highly chemoselective procedure for protection of aldehydes in the presence of ketones, and the heterogeneous catalyst can be recovered and reused several times without any loss of its activity. Copyright Taylor & Francis Group, LLC.