5664-17-5Relevant articles and documents
THE IR, RAMAN AND NMR SPECTRA AND CONFORMATIONS OF CYCLOHEXYLALLENE
Gatial, A.,Horn, A.,Klaeboe, P.,Nielsen, C. J.,Pedersen, B.,et al.
, p. 59 - 66 (1990)
Three conformers of cyclohexylallene, designated I, II and III, were observed in the IR and Raman spectra.Metastable crystals formed by annealing an amorphous solid from 80 K to 140 K, and crystals formed under a pressure of 30 kbar at ambient temperature, contained conformer II.The stable crystals obtained after heating the metastable crystals to 195 K contained conformer I.The conformer III was observed as a minor component in a nitrogen matrix heated to 900 K before deposition.Negligible intensity variations between the bands of conformer I and II were observedwith nozzle temperatures 300-900 K in the argon and nitrogen matrices, indicating a ΔH0(I-II) below 0.4 kJ mol-1 while ΔH0(III-II) was equal to 6.5 kJ mol-1 and a barrier higher than ca. 11 kJ mol-1 was observed between the latter.Variable temperature measurements in Raman indicate ΔH0(I-II) ca. 0.9 kJ mol-1 in the liquid.The 13C NMR spectra show that in deuteromethanol solution the equatorial conformer dominates ( = 2percent a at 193 K, ΔG0(a-e) ca. 6.4 kJ mol-1).Analysing the temperature dependence of the vicinal H-H coupling across the cyclohexane - allene carbon bond on the basis of a gauche anti equilibrium it is found 40percent anti and 60percent gauche in methanol solution at ambient temperature.We conclude that the abundant conformers II and I being respectively the anti and the gauche conformer, while III is the anti axial conformer.
Preparation of (E)-1,3-Enyne Derivatives through Palladium Catalyzed Hydroalkynylation of Allenes
Liu, Zhi-Kai,Yang, Ying,Zhan, Zhuang-Ping
supporting information, p. 1589 - 1597 (2022/01/20)
A general and efficient palladium catalyzed hydroalkynylation of allenes was developed to produce synthetically versatile (E)-1,3-enyne derivatives with high regio- and stereoselectivity. This catalytic system proceeded under mild conditions and was compatible with a broad range of substrates, especially for allenes without electron-bias groups. This work further broadens the synthetic potential of these scaffolds in organic synthesis and medicinal chemistry.
Palladium-Catalyzed Carbonylative Four-Component Synthesis of β-Perfluoroalkyl Amides
Geng, Hui-Qing,Wu, Xiao-Feng,Zhang, Youcan
supporting information, p. 17682 - 17687 (2021/10/25)
Transition-metal-catalyzed multicomponent carbonylation is one of the most efficient strategies to construct carbonyl-containing compounds. Herein, a palladium-catalyzed four-component perfluoroalkylation/aminocarbonylation of unactivated alkenes with per
A 1, 1 - disubstituted [...] compound synthesis method
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Paragraph 0055-0057, (2019/03/28)
The invention discloses a 1, 1 - disubstituted [...] compound synthesis method, the catalyst cuprous chloride, carbene precursor, the tertiary butyl alcohol potassium is added in the Schlenk reaction tube, vacuum, in an inert gas conditions, adding tetrahydrofuran, stir; then the [...][...], type I shown and methanol is dissolved in the tetrahydrofuran zincon after, in the Schlenk reaction tube of the instillment to states, for 25 °C stirring for 1 - 5 hours, the resulting reaction solution after treatment of formula II shown in 1, 1 - disubstituted [...] compound. Synthesis method of the invention has catalyst is cheap and easy to obtain and the low toxicity, high selectivity, environment friendly, mild reaction conditions, functional group universal good and simple operation and the like.