56681-97-1

Basic information

• Product Name: 4,4-Dimethoxybutanal
• Synonyms: 4,4-Dimethoxybutanal;4,4-Dimethoxybutyraldehyde
• CAS NO: 56681-97-1
• Molecular Formula: C₆H₁₂O₃
• Molecular Weight: 132.15768
• Mol File: 56681-97-1.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4,4-Dimethoxybutanal(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4-Dimethoxybutanal(56681-97-1)
• EPA Substance Registry System: 4,4-Dimethoxybutanal(56681-97-1)

Safety Data

• Hazardous Substances Data: 56681-97-1(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 1165952-91-9 cyclohexa-1,3-diene 
• 14618-78-1 4,4-dimethoxybutanenitrile 
• 63284-78-6 (4Z)-1,1,8,8-tetramethoxyoct-4-ene 
• 4220-66-0 methyl 4,4-dimethoxybutanoate 
• 6044-68-4 3,3-dimethoxyprop-1-ene 
• 107-02-8 acrolein 

Downstream Products

• 332072-71-6 (R)-(-)-N-(4,4-dimethoxybutanylidene)-p-toluenesulfinimide 
• 911857-32-4 4-(3,3-dimethoxypropyl)-6-phenyl-2-pyrazol-1-yl-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester 
• 902454-51-7 C₁₈H₂₈O₄ 
• 902454-52-8 C₂₂H₃₄O₆ 
• 902454-53-9 C₂₀H₃₂O₅ 
• 911857-42-6 2-amino-6-(3,3-dimethoxypropyl)-4-phenyl-6H-pyrimidine-1,5-dicarboxylic acid 1-tert-butyl ester 5-ethyl ester 
• 911857-37-9 6-(3,3-dimethoxypropyl)-4-phenyl-2-pyrazol-1-yl-6H-pyrimidine-1,5-dicarboxylic acid 1-tert-butyl ester 5-ethyl ester 
• 911857-43-7 2-amino-6-(3,3-dimethoxypropyl)-4-(4-nitrophenyl)-6H-pyrimidine-1,5-dicarboxylic acid 1-tert-butyl ester 5-ethyl ester 
• 911857-38-0 6-(3,3-dimethoxypropyl)-4-(4-nitrophenyl)-2-pyrazol-1-yl-6H-pyrimidine-1,5-dicarboxylic acid 1-tert-butyl ester 5-ethyl ester 
• 823785-38-2 4-methoxy-6-phenylhex-5-ynal 
• 135781-97-4 2-benzyl-3-methoxylcyclopent-2-enone 
• 713525-97-4 (S_S,R)-(+)-O,O-diethyl N-(p-toluenesulfinyl)-1-amino-4,4-dimethoxybutylphosphonate 
• 424835-12-1 2-methoxy-5-(3-phenylsulfanyl-but-3-enyl)-tetrahydro-furan 
• 219130-10-6 2-((1E,3E)-7,7-Dimethoxy-3-methyl-hepta-1,3-dienyl)-1,3,3-trimethyl-cyclohexene 

Relevant articles and documents

A Convenient Preparation of 4,4-Dimethoxybutanal by Ozonolysis of 1,5-Cyclooctadiene

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A Modular and Diastereoselective 5 + 1 Cyclization Approach to N-(Hetero)Aryl Piperidines

A new general de novo synthesis of pharmaceutically important N-(hetero)aryl piperidines is reported. This protocol uses a robustly diastereoselective reductive amination/aza-Michael reaction sequence to achieve rapid construction of complex polysubstituted ring systems starting from widely available heterocyclic amine nucleophiles and carbonyl electrophiles. Notably, the diastereoselectivity of this process is enhanced by the presence of water, and DFT calculations support a stereochemical model involving a facially selective protonation of a water-coordinated enol intermediate.

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