5672-89-9 Usage
Description
N-Succinimidyl Trifluoroacetate, also known as O-(Trifluoroacetyl)-N-hydroxysuccinimide, is a chemical compound commonly utilized in various applications across different industries. It is characterized by its ability to react with amines to form stable amide bonds, making it a versatile reagent in chemical synthesis and modification processes.
Uses
Used in Fluorescent Dye Synthesis:
N-Succinimidyl Trifluoroacetate is used as a reagent for the preparation of fluorinated xanthene derivatives, which serve as fluorescent dyes. These dyes are particularly useful in the staining of biological materials, allowing for enhanced visualization and analysis in various research and diagnostic applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, N-Succinimidyl Trifluoroacetate is employed as a protecting group for amines during chemical synthesis. This protects the amine group from unwanted reactions, ensuring the selective modification of other functional groups in the molecule. This application is crucial for the development of new drugs and the synthesis of complex pharmaceutical compounds.
Used in Biochemical Research:
N-Succinimidyl Trifluoroacetate is also used in biochemical research as a tool for the modification of proteins and other biomolecules. By forming stable amide bonds with amine groups, it allows for the attachment of various functional groups or tags to the biomolecule of interest, facilitating its detection, purification, or further modification.
Used in Chemical Synthesis:
In the broader field of chemical synthesis, N-Succinimidyl Trifluoroacetate is used as a coupling agent to promote the formation of amide bonds between carboxylic acids and amines. This is particularly useful in the synthesis of peptides, peptidomimetics, and other amide-containing compounds, enabling the efficient and selective formation of the desired products.
Check Digit Verification of cas no
The CAS Registry Mumber 5672-89-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,6,7 and 2 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 5672-89:
(6*5)+(5*6)+(4*7)+(3*2)+(2*8)+(1*9)=119
119 % 10 = 9
So 5672-89-9 is a valid CAS Registry Number.
5672-89-9Relevant articles and documents
Argininamide-type neuropeptide y Y1 receptor antagonists: The nature of: N Ω-carbamoyl substituents determines Y1R binding mode and affinity
Buschmann, Jonas,Keller, Max,Seiler, Theresa,Wifling, David,Bernhardt, Günther
supporting information, p. 274 - 282 (2020/04/17)
The recently resolved crystal structure of the neuropeptide Y Y1 receptor (Y1R), co-crystallized with the high-affinity (pKi: 10.11), argininamide-type Y1R antagonist UR-MK299 (2), revealed that the NΩ-carbamoyl substituent (van der Waals volume: 139 ?3) is deeply buried in the receptor, occupying a hydrophobic pocket. We synthesized and characterized a series of argininamides, structurally related to 2. Y1R affinity decreased with increasing size of the carbamoyl residue (minimal pKi: 5.67). Exceeding a critical size of the substituent (van der Waals volume: 212 ?3), the ligands bound in an inverted mode with the carbamoyl side chain located at the surface of the receptor, as suggested by induced-fit docking and MD simulations.
Synthesis and Antitumor Activity of Conjugates Based on the Phe-D-Trp-Lys-Thr Peptide Fragment of Somatostatin
Avdeev,Sidorova,Ovchinnikov,Moiseeva,Osipov,Balaev,Khachatryan
, p. 248 - 252 (2019/09/10)
Abstract: New somatostatin analogs containing the fragments of adamantane, coumarin, tetrahydrocarbazole, and palmitic acid of the general formula R-Phe-D-Trp-Lys(Boc)-Thr-OMe have been synthesized. The structure of the conjugates combines a peptide fragm
A Practical Synthesis of 6,8-Difluoro-7-hydroxycoumarin Derivatives for Fluorescence Applications
Kerkovius, Jeff K.,Menard, Frederic
, p. 1622 - 1629 (2016/05/24)
A practical synthesis for 6,8-difluoro-7-hydroxycoumarin-3-carboxylic acid - one of the most widely used coumarin fluorescence imaging dye for bioconjugation - is reported. The synthesis was optimized for a preparative scale to obtain 14 g of the fluoresc
