56734-74-8

Basic information

• Product Name: 2-(TRIFLUOROMETHYL)CYCLOHEXANONE
• Synonyms: trifluoromethylcyclohexanone;2-(TRIFLUOROMETHYL)CYCLOHEXANONE;2-(Trifluoromethyl)cyclohexanone97%;2-(Trifluoromethyl)cyclohexanone 97%
• CAS NO: 56734-74-8
• Molecular Formula: C₇H₉F₃O
• Molecular Weight: 166.14
• Mol File: 56734-74-8.mol
• Article Data: 31

Chemical Properties

• Boiling Point: 74°C 18mm
• Flash Point: 44℃
• Appearance: /
• Density: 1.221g/cm³
• Vapor Pressure: 2.92mmHg at 25°C
• Refractive Index: 1.394
• CAS DataBase Reference: 2-(TRIFLUOROMETHYL)CYCLOHEXANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(TRIFLUOROMETHYL)CYCLOHEXANONE(56734-74-8)
• EPA Substance Registry System: 2-(TRIFLUOROMETHYL)CYCLOHEXANONE(56734-74-8)

Safety Data

• Hazard Codes: Xi
• Statements: 10-20/21/22
• Safety Statements: 16-23-36/37/39
• RIDADR: 1993
• HazardClass: IRRITANT
• Hazardous Substances Data: 56734-74-8(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 31, p. 3579, 1990 DOI: 10.1016/S0040-4039(00)94447-2

InChI:InChI=1/C7H9F3O/c8-7(9,10)5-3-1-2-4-6(5)11/h5H,1-4H2

Upstream product

• 1125-99-1 1-(1-Cyclohexen-1-yl)pyrrolidine 
• 2314-97-8 iodotrifluoromethane 
• 75-63-8 Bromotrifluoromethane 
• 1184-76-5 difluorodiiodomethane 
• 129946-88-9 Umemoto's reagent 
• 670-80-4 4-cyclohexen-1-ylmorpholine 
• 80176-65-4 1-Cyclohexylidene-pyrrolidinium; chloride 
• 6651-36-1 1-(Trimethylsilyloxy)cyclohexene 
• 444-30-4 2-(trifluoromethyl)phenol 
• 80404-82-6 2-(1-chloro-1,1-difluoromethyl)cyclohexanone 
• 80404-81-5 2-(Bromo-difluoro-methyl)-cyclohexanone 
• 67-63-0 isopropyl alcohol 
• 109915-34-6 6-trifluoromethyl-2-cyclohexenone 
• 2926-29-6 Langlois reagent 

Downstream Products

• 104282-19-1 cis-, trans-2-(trifluoromethyl)cyclohexanol 
• 91404-90-9 methyl 7,7,7-trifluoroheptanoate 
• 75091-90-6 (1R,2R)-2-Trifluoromethyl-cyclohexanol 
• 109915-34-6 6-trifluoromethyl-2-cyclohexenone 
• 920966-40-1 (1R,2S)-N-[(1R)-1-phenylethyl]-2-(trifluoromethyl)cyclohexanamine 
• 1039762-36-1 2-(trifluoromethyl)-2-(2-cyanoethyl)-cyclohexanone 

Relevant articles and documents

"Pseudo-Cationic" Trifluoromethylation of Enol Esters with Sodium Trifluoromethanesulfinate.

Enol esters are converted into corresponding trifluoromethylated ketones and/or enol esters with sodium trifluoromethanesulfinate and t-butyl hydroperoxide in the presence of catalytic amounts of Cu(II). Key Words: trifluoromethylation; enol esters; sodiu

Direct C(sp3)?H Trifluoromethylation of Unactivated Alkanes Enabled by Multifunctional Trifluoromethyl Copper Complexes

A mild and operationally simple C(sp3)?H trifluoromethylation method was developed for unactivated alkanes by utilizing a bench-stable CuIII complex, bpyCu(CF3)3, as the initiator of the visible-light photoinduced reaction, the source of a trifluoromethyl radical as a hydrogen atom transfer reagent, and the source of a trifluoromethyl anion for functionalization. The reaction was initiated by the generation of reactive electrophilic carbon-centered CF3 radical through photoinduced homolytic cleavage of bpyCu(CF3)3, followed by hydrogen abstraction from an unactivated C(sp3)?H bond. Comprehensive mechanistic investigations based on a combination of experimental and computational methods suggested that C?CF3 bond formation was enabled by radical–polar crossover and ionic coupling between the resulting carbocation intermediate and the anionic CF3 source. The methylene-selective reaction can be applied to the direct, late-stage trifluoromethylation of natural products and bioactive molecules.

Radical Desulfur-Fragmentation and Reconstruction of Enol Triflates: Facile Access to α-Trifluoromethyl Ketones

We report an efficient oxidative radical desulfur-fragmentation and reconstruction of enol triflates for the synthesis of α-CF3ketones. Preliminary mechanistic studies disclosed that oxidative fragmentation to release a CF3radical fr