5681-33-4

Basic information

• Product Name: 2-(naphthalen-2-yl)-3-phenylpropanenitrile
• Synonyms: 2-(naphthalen-2-yl)-3-phenylpropanenitrile
• CAS NO: 5681-33-4
• Molecular Weight: 257.335
• Mol File: 5681-33-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-(naphthalen-2-yl)-3-phenylpropanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(naphthalen-2-yl)-3-phenylpropanenitrile(5681-33-4)
• EPA Substance Registry System: 2-(naphthalen-2-yl)-3-phenylpropanenitrile(5681-33-4)

Safety Data

• Hazardous Substances Data: 5681-33-4(Hazardous Substances Data)

Upstream product

• 7498-57-9 2-naphthaleneacetonitrile 
• 100-51-6 benzyl alcohol 
• 1589-82-8 phenylmagnesium bromide 
• 66-99-9 β-naphthaldehyde 
• 220063-61-6 1-(naphthalen-2-yl)-2-phenylethan-1-ol 
• 100-39-0 benzyl bromide 

Downstream Products

• 132505-55-6 N-Hydroxy-2-naphthalen-2-yl-3-phenyl-propionamidine 

Relevant articles and documents

Base-controlled chemoselectivity: direct coupling of alcohols and acetonitriles to synthesise α-alkylated arylacetonitriles or acetamides

We achieved chemoselective synthesis of α-alkylated arylacetonitriles and acetamides by combining Ir complex-catalysed direct coupling of alcohols and nitriles by a simple adjustment of the base. Methanol and ethanol performed well as the alkylating reagents. This method of acetonitrile alkylation provided a novel approach for carbon chain extension.

Asymmetric Deoxygenative Cyanation of Benzyl Alcohols Enabled by Synergistic Photoredox and Copper Catalysis?

Summary of main observation and conclusion. An enantioselective deoxygenative cyanation of benzyl alcohols was accomplished for the first time through the synergistic photoredox and copper catalysis. This reaction features the use of organic photosensitizer and low-cost 3d metal catalyst, simple and safe operations, and extremely mild conditions. A variety of chiral benzyl nitriles were produced in generally good yields and high level of enantiocontrols from readily available feedstocks (22 examples, up to 93% yield and 92% ee).

Novel naphthalenyl-3H-1,2,3,5-oxathiadiazole 2-oxides useful as antihyperglycemic agents

This invention relates to novel substituted 3H-1,2,3,5-oxathiadiazole 2-oxides, processes for their preparation, to methods for using the compounds, and to pharmaceutical preparations thereof. The compounds have pharmaceutical properties which render them beneficial for the treatment of diabetes mellitus and associated conditions.