56956-66-2

Basic information

• Product Name: 2,6-Morpholinedione, 4-phenyl-
• CAS NO: 56956-66-2
• Molecular Formula: C10H9NO3
• Molecular Weight: 191.186
• Mol File: 56956-66-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2,6-Morpholinedione, 4-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Morpholinedione, 4-phenyl-(56956-66-2)
• EPA Substance Registry System: 2,6-Morpholinedione, 4-phenyl-(56956-66-2)

Safety Data

• Hazardous Substances Data: 56956-66-2(Hazardous Substances Data)

Upstream product

• 1137-73-1 N,N-bis(carboxymethyl)aniline 
• 55932-12-2 phenyliminodiacetic acid diethyl ester 
• 62-53-3 aniline 

Downstream Products

• 24783-70-8 N-benzoselenazol-2-ylmethyl-N-phenyl-glycine 
• 31183-94-5 N-benzothiazol-2-ylmethyl-N-phenyl-glycine 
• 144038-11-9 1-{[2-Oxo-3-(triphenyl-λ⁵-phosphanylidene)-propyl]-phenyl-amino}-3-(triphenyl-λ⁵-phosphanylidene)-propan-2-one 
• 161555-27-7 (Methoxycarbonylmethyl-phenyl-amino)-acetic acid 
• 161555-23-3 [(2-Ethoxymethoxy-ethyl)-phenyl-amino]-acetic acid methyl ester 
• 24783-85-5 N-benzoselenazol-2-ylmethyl-N-phenyl-glycine amide 
• 24783-77-5 N-benzoselenazol-2-ylmethyl-N-phenyl-glycine methyl ester 
• 31184-07-3 2-(N-benzothiazol-2-ylmethyl-anilino)-ethanol 
• 31184-03-9 N-benzothiazol-2-ylmethyl-N-phenyl-glycine amide 
• 31184-00-6 N-benzothiazol-2-ylmethyl-N-phenyl-glycine methyl ester 
• 31184-05-1 N-benzothiazol-2-ylmethyl-N-phenyl-glycine hydrazide 
• 31184-01-7 N-benzothiazol-2-ylmethyl-N-phenyl-glycine ethyl ester 
• 42239-75-8 4-phenylpiperazine-2,6-dione 

Relevant articles and documents

Modulators of hERAP2 discovered by high-throughput screening

Endoplasmic reticulum aminopeptidase 2, ERAP2, is an emerging pharmacological target in cancer immunotherapy and control of autoinflammatory diseases, as it is involved in antigen processing. It has been linked to the risk of development of spondyloarthritis, and it associates with the immune infiltration of tumours and strongly predicts the overall survival for patients receiving check-point inhibitor therapy. While some selective inhibitors of its homolog ERAP1 are available, no selective modulator of ERAP2 has been disclosed so far. In order to identify such compounds, we screened an in-house focused library of 1920 compounds designed to target metalloenzymes. Structure-Activity Relationships and docking around two hits led to the discovery of selective inhibitors of ERAP2. Amid those, some bind to yet untapped amino-acids in the S1 pocket. Importantly, we disclose also the first activator of small substrates hydrolysis by ERAP2. Inhibitors and activators identified in this study could serve as useful starting points for optimization.

Design, synthesis and structure-activity relationship studies of morpholino-1H-phenalene derivatives that antagonize Mcl-1/Bcl-2

We report herein characteristic studies of Mcl-1 and Bcl-2 dual inhibitors. It was found that a protruding carbonyl group forming hydrogen bond with R263 plays a predominant role compared with the hydrophobic group that occupies the p2 pocket. A series of dual inhibitors representing different parts of the morpholino-1H-phenalene were designed, synthesized and evaluated.