56961-87-6

Basic information

• Product Name: 2-Chloro-3-Methylacetanilide
• Synonyms: Acetamide, N-(2-chloro-3-methylphenyl)-
• CAS NO: 56961-87-6
• Molecular Formula: C₉H₁₀ClNO
• Molecular Weight: 183.6348
• Mol File: 56961-87-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Chloro-3-Methylacetanilide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-3-Methylacetanilide(56961-87-6)
• EPA Substance Registry System: 2-Chloro-3-Methylacetanilide(56961-87-6)

Safety Data

• Hazardous Substances Data: 56961-87-6(Hazardous Substances Data)

Usage

General Description

2-Chloro-3-Methylacetanilide, also known as diclofenac, is a nonsteroidal anti-inflammatory drug (NSAID) that is commonly used to treat pain and inflammation. It works by inhibiting the production of chemicals in the body that cause pain and inflammation. This chemical is commonly used to treat conditions such as arthritis, menstrual cramps, and migraines. It is available in various forms, including tablets, capsules, and topical gels. While generally considered safe and effective, it can cause side effects such as stomach pain, heartburn, and dizziness, and should be used with caution, especially in individuals with a history of stomach ulcers or bleeding disorders.

Upstream product

• 29027-17-6 2-chloro-3-methylaniline 
• 108-24-7 acetic anhydride 
• 7647-01-0 hydrogenchloride 
• 537-92-8 3-Methylacetanilide 
• 64-19-7 acetic acid 

Downstream Products

• 101870-46-6 3-(acetylamino)-4-chlorobenzoic acid 
• 19853-80-6 acetic acid-(2,4-dichloro-3-methyl-anilide) 
• 249289-91-6 3-acetylamino-2-chloro-benzoic acid 
• 70383-10-7 N-(2-chloro-3-methylphenyl)-N-methylacetanilide 
• 143360-06-9 C₉H₉BrClNO 
• 573767-71-2 4-amino-3-chloro-2-methylbenzonitrile 
• 50-31-7 2,3,6-TBA 
• 2077-46-5 1,2,4-trichloro-3-methylbenzene 
• 19853-79-3 2,4-dichloro-3-methylaniline 
• 115423-97-7 2,3,6-trichloro-4,5-dinitro-toluene 
• 500881-08-3 2,3,6-trichloro-5-nitro-toluene 

Relevant articles and documents

Acylation of Phenols, Alcohols, Thiols, Amines and Aldehydes Using Sulfonic Acid Functionalized Hyper-Cross-Linked Poly(2-naphthol) as a Solid Acid Catalyst

Abstract: The hyper-cross-linked porous poly(2-naphthol) fabricated by the Friedel–Crafts alkylation of 2-naphthol has been functionalized with sulfonic acid to obtain a solid acid catalyst. The catalyst is applied for the protection of phenol, alcohols, thiols, amines and aldehydes with acetic anhydride at room temperature. The catalytic protection using the new solid acid is featured by achieving high yield at neat condition, needing no aqueous work-up and/or chromatographic separation, and showing excellent recycling efficiency, suggesting the potential of this sulfonated porous polymers as a new protection protocol in a wide range of sustainable chemical reactions. Graphical Abstract: [Figure not available: see fulltext.].

Photoinduced Cyclizations of Mono- and Dianions of N-Acyl-o-chloroanilines and N-Acyl-o-chlorobenzylamines as General Methods for the Synthesis of Oxindoles and 1,4-Dihydro-3(2H)-isoquinolinones

Formation of the monoanions of a series of N-acyl-N-alkyl-o-chloroanilines by means of LDA in THF followed by irradiation with near-UV light affords 1,3-dialkyloxindoles in good yields.Similar photoinduced cyclizations of dianions derived from N-acyl-o-chloroanilines leads to 3-alkyloxindoles.Photocyclizations of mono- and dianion prepared from α,β-unsaturated o-haloanilides proceed to form 3-alkylideneoxindoles.Carbanions derived from N-acyl-o-chlorobenzylamines also undergo photoassisted ring closure to afford 1,4-dihydro-3(2H)-isoquinolinones.The influence of near-UV light and the effect of inhibitors implicate a radical-chain mechanism as the major reaction pathway in this convenient new method for oxindole and isoquinolinone synthesis.