56962-01-7

Basic information

• Product Name: Phenol, 3-amino-2-chloro-
• Synonyms: Phenol, 3-amino-2-chloro-;3-Amino-2-chlorophenol
• CAS NO: 56962-01-7
• Molecular Formula: C₆H₆ClNO
• Molecular Weight: 143.57
• Product Categories: Drug Intermediates
• Mol File: 56962-01-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 110-111 °C
• Boiling Point: 253 °C at 760 mmHg
• Flash Point: 106.8 °C
• Appearance: /
• Density: 1.406 g/cm³
• Vapor Pressure: 0.0118mmHg at 25°C
• Refractive Index: 1.65
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: Phenol, 3-amino-2-chloro-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 3-amino-2-chloro-(56962-01-7)
• EPA Substance Registry System: Phenol, 3-amino-2-chloro-(56962-01-7)

Safety Data

• Hazardous Substances Data: 56962-01-7(Hazardous Substances Data)

Usage

Description

Phenol, 3-amino-2-chloro-, also known as 3-Amino-2-chlorophenol, is an organic compound derived from phenol with an amino group at the 3rd position and a chlorine atom at the 2nd position. It exhibits unique chemical properties due to the presence of these functional groups, making it a versatile compound for various applications in different industries.

Uses

Used in Pharmaceutical Industry:
Phenol, 3-amino-2-chlorois used as a reagent for the preparation of phenol quinazolines, which are significant as RET kinase inhibitors. These inhibitors play a crucial role in the development of targeted therapies for various cancers, as they help regulate the abnormal cell growth and signaling pathways associated with tumor progression.

InChI:InChI=1/C6H6ClNO/c7-6-4(8)2-1-3-5(6)9/h1-3,9H,8H2

Upstream product

• 603-84-9 2-chloro-3-nitrophenol 
• 38902-87-3 3-nitro-2,4-dichlorophenol 
• 113206-03-4 2-chloro-3-methoxyphenylamine 

Downstream Products

• 576-24-9 2,3-dichlorophenol 

Relevant articles and documents

SECOND GENERATION INHIBITORS OF MITOCHONDRIAL PERMEABILITY TRANSITION PORE WITH IMPROVED PLASMA STABILITY

The present invention provides compounds useful as mitochondrial permeability transition pore (mtPTP) inhibitors, the compounds being of Formula (I), or a pharmaceutically acceptable salt thereof wherein R11 is selected from the group of H, halogen, and C11-C33 alkyl; and R22 is selected from the group of H, CF33, and halogen; with the proviso that at least one of R11 and R22 is halogen or CF33.

Highly selective hydrogenation of aromatic chloronitro compounds to aromatic chloroamines with ionic-liquid-like copolymer stabilized platinum nanocatalysts in ionic liquids

Platinum nanoparticles (PtNPs stabilized by an ionic-liquid-like-copolymer (IP) immobilized in various ionic liquids (ILs)) effectively catalyze the selective hydrogenation of aromatic chloronitro compounds to aromatic chloroamines, a reaction of considerable commercial significance. The preparation of 2,4-dichloro-3-aminophenol (DAP) has been primarily studied due to its important industrial applications. DAP is usually prepared from 2,4-dichloro-3-nitrophenol (DNP) by reduction with hydrogen using Ni- or Pt-based catalysts. Compared to reactions in molecular (organic) solvents, the ILs system provides superior selectivity with functionalized ILs containing an alcohol group demonstrating the best recyclability, and ultimately achieving a turnover number of 2025 which is 750 fold higher than Raney nickel catalyst. A universal catalyst-ionic liquid system for the conversion of aromatic chloronitro compounds to aromatic chloroamines was also established. TEM, XPS, IR spectroscopy were used to characterize the morphology of the nanocatalysts allowing their structure to be correlated to their activity.