56980-94-0

Basic information

• Product Name: 5-Amino-2-(3-(tert-butylamino)-2-hydroxypropoxy)acetophenone
• Synonyms: 5-Amino-2-(3-(tert-butylamino)-2-hydroxypropoxy)acetophenone;1-[5-amino-2-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]ethanone;3-Acetyl-4-[3-(1,1-Dimethylethylamino)-2-Hydroxy-Propoxy]Aniline;1-[5-AMino-2-[3-[(1,1-diMethylethyl)aMino]-2-hydroxypropoxy]phenyl]ethanone;Celiprolol hydrochloride impurity A
• CAS NO: 56980-94-0
• Molecular Formula: C15H24N2O3
• Molecular Weight: 280.36266
• EINECS: 923-159-6
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 56980-94-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 472.1°Cat760mmHg
• Flash Point: 239.3°C
• Appearance: /
• Density: 1.107g/cm³
• Vapor Pressure: 1.02E-09mmHg at 25°C
• Refractive Index: 1.545
• Storage Temp.: Refrigerator
• Solubility: Chloroform, Dichloromethane, Ethyl Acetate, Methanol
• CAS DataBase Reference: 5-Amino-2-(3-(tert-butylamino)-2-hydroxypropoxy)acetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Amino-2-(3-(tert-butylamino)-2-hydroxypropoxy)acetophenone(56980-94-0)
• EPA Substance Registry System: 5-Amino-2-(3-(tert-butylamino)-2-hydroxypropoxy)acetophenone(56980-94-0)

Safety Data

• Hazardous Substances Data: 56980-94-0(Hazardous Substances Data)

Usage

Chemical Properties

Yellow-Brown Solid

InChI:InChI=1/C15H24N2O3/c1-10(18)13-7-11(16)5-6-14(13)20-9-12(19)8-17-15(2,3)4/h5-7,12,17,19H,8-9,16H2,1-4H3

Upstream product

• 329722-32-9 1-[2-(3-tert-butylamino-2-hydroxy-propoxy)-5-nitro-phenyl]-ethanone 
• 850427-85-9 allyl 2-acetyl-4-nitrophenyl ether 
• 850427-98-4 (2S)-3-(2-acetyl-4-nitrophenoxy)-1,2-epoxypropane 
• 850427-87-1 (S)-3-(2'-acetyl-4'-nitrophenoxy)-1,2-propanediol 
• 850427-91-7 1-[5-Nitro-2-((R)-2-oxo-2λ⁴-[1,3,2]dioxathiolan-4-ylmethoxy)-phenyl]-ethanone 
• 850427-97-3 1-[2-((R)-2,2-Dioxo-2λ⁶-[1,3,2]dioxathiolan-4-ylmethoxy)-5-nitro-phenyl]-ethanone 
• 1450-76-6 1-(2-hydroxy-5-nitrophenyl)ethanone 
• 100-02-7 4-nitro-phenol 
• 830-03-5 4-nitrophenol acetate 
• 329722-31-8 1-[5-nitro-2-(oxiran-2-ylmethoxy)phenyl]ethan-1-one 
• 329722-32-9 1-{2-[3-(tert-butylamino)-2-hydroxypropoxy]-5-nitrophenyl}ethan-1-one 

Relevant articles and documents

Asymmetric synthesis of aryloxypropanolamines via OsO4-catalyzed asymmetric dihydroxylation

A simple and effective procedure for the enantioselective synthesis of several β-adrenergic blocking agents incorporating the first asymmetric synthesis of celiprolol, is described. The key steps are (i) sharpless asymmetric dihydroxylation of aryl allyl ethers to introduce chirality into the molecules and (ii) conversion of cyclic sulfates into the corresponding epoxides using a three-step procedure.