57014-02-5 Usage
Description
Calcitonin eel is a peptide hormone that plays a crucial role in regulating calcium homeostasis in the body. It is released by thyroid cells and acts to decrease the formation and absorptive activity of osteoclasts, thereby lowering calcium concentration in the blood. Its role in calcium regulation is particularly significant in children and in certain diseases, such as postmenopausal osteoporosis.
Uses
Used in Pharmaceutical Industry:
Calcitonin eel is used as a therapeutic agent for the treatment of osteoporosis, particularly in postmenopausal women. It helps to increase bone density and reduce the risk of fractures by slowing down bone resorption and promoting bone formation.
Used in Research:
Calcitonin eel is widely used in research studies to investigate the mechanisms of bone metabolism and the development of new treatments for bone-related disorders, such as osteoporosis and Paget's disease of bone.
Used in Diagnostics:
Calcitonin eel can be used as a diagnostic marker to assess bone turnover and monitor the effectiveness of treatments for bone-related conditions.
Used in Veterinary Medicine:
Calcitonin eel can also be used in veterinary medicine to manage bone disorders and promote bone health in animals.
Biological Activity
Calcitonin is hypocalcemic hormone produced by the parafollicular C cells of the thyroid or by the ultimobranchial bodies of nonmammalian vertebrates. Calcitonin decreases blood calcium and phosphate due to inhibition of resorption by osteoblasts and osteocytes.
in vitro
Calcitonin, eel effectively induces a concentration-dependent stimulation of phosphoinositide hydrolysis and stimulates prolactin release compared to salmon calcitonin in cultured anterior pituitary cells.Calcitonin, eel is inactive on the inhibition of prolactin release under thyrotropin releasing hormone (TRH) stimulated conditions.
Structure and conformation
Eel calcitonin has structural similarities with salmon calcitonin and, to date, research preparations have been evaluated with reference to the salmon calcitonin standard using the rat hypocalcaemia assay method. However, as salmon and eel calcitonins do have structural differences, which are likely to become evident if different in vivo or in vitro assay methods are used, a standard for eel calcitonin is required.
Check Digit Verification of cas no
The CAS Registry Mumber 57014-02-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,0,1 and 4 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 57014-02:
(7*5)+(6*7)+(5*0)+(4*1)+(3*4)+(2*0)+(1*2)=95
95 % 10 = 5
So 57014-02-5 is a valid CAS Registry Number.
InChI:InChI=1/C146H243N43O47S2/c1-66(2)47-88(175-140(231)112(72(13)14)184-137(228)100(64-238)181-143(234)115(76(18)195)187-136(227)99(62-192)180-130(221)92(51-70(9)10)172-132(223)94(54-105(152)200)174-135(226)97(60-190)178-119(210)81(149)63-237)120(211)159-58-107(202)163-82(27-20-22-42-147)121(212)169-91(50-69(7)8)129(220)179-98(61-191)134(225)167-85(36-39-103(150)198)123(214)165-87(38-41-109(204)205)124(215)171-90(49-68(5)6)128(219)173-93(53-79-56-156-65-161-79)131(222)164-83(28-21-23-43-148)122(213)170-89(48-67(3)4)127(218)166-86(37-40-104(151)199)126(217)186-114(75(17)194)142(233)177-96(52-78-32-34-80(197)35-33-78)144(235)189-46-26-31-102(189)138(229)168-84(29-24-44-157-146(154)155)125(216)185-113(74(16)193)141(232)176-95(55-110(206)207)133(224)183-111(71(11)12)139(230)160-57-106(201)162-73(15)118(209)158-59-108(203)182-116(77(19)196)145(236)188-45-25-30-101(188)117(153)208/h32-35,56,65-77,81-102,111-116,190-197,237-238H,20-31,36-55,57-64,147-149H2,1-19H3,(H2,150,198)(H2,151,199)(H2,152,200)(H2,153,208)(H,156,16
