57335-02-1

Basic information

• Product Name: 2-bromo-5-methoxy-4-methylphenylacetonitrile
• Synonyms: 2-bromo-5-methoxy-4-methylphenylacetonitrile
• CAS NO: 57335-02-1
• Molecular Weight: 240.099
• Mol File: 57335-02-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-bromo-5-methoxy-4-methylphenylacetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-5-methoxy-4-methylphenylacetonitrile(57335-02-1)
• EPA Substance Registry System: 2-bromo-5-methoxy-4-methylphenylacetonitrile(57335-02-1)

Safety Data

• Hazardous Substances Data: 57335-02-1(Hazardous Substances Data)

Upstream product

• 4685-50-1 3-methoxy-4-methylbenzyl alcohol 
• 24973-22-6 3-methoxy-4-methylbenzaldehyde 
• 64829-31-8 2-(3-methoxy-4-methylphenyl)acetonitrile 
• 57295-30-4 3-hydroxy-4-methylbenzaldehyde 

Downstream Products

• 75156-81-9 methyl α-bromo-(2-bromo-5-methoxy-4-methylphenyl)acetate 
• 75156-82-0 methyl α-bromo-(2-bromo-5-methoxy-4-methoxymethylphenyl)acetate 
• 75156-86-4 methyl α-<3-acetoxy-4-(N-ethoxycarbonyl-N-methylamino)-pyrrolidin-2-ylidene>-α-(2-bromo-5-methoxy-4-methoxymethylphenyl)-acetate 
• 75097-32-4 2-bromo-5-methoxy-4-methylphenylacetic acid 

Relevant articles and documents

Studies on the Synthesis of Heterocyclic Compounds. Part 832. A Simple and Efficient Synthesis of Apomitomycin Derivatives; a Potential Intermediate for Mitomycin Synthesis

Condensation of pyrrolidine-2-thione (21) with methyl α-bromo-(2-bromo-4,5-dimethoxyphenyl)acetate (15) gave methyl (Z)-α-(2-bromo-4,5-dimethoxyphenyl)-α-pyrrolidin-2-ylideneacetate (25) in high yield.Several other methyl (Z)-α-aryl-α-acetates (26)-(31) were also synthesised in good yields from reaction of the corresponding phenylacetates (15), (12), and (13) with trans-3-acetoxy-4-(N-ethoxycarbonyl-N-methylamino)pyrrolidine-2-thione (20).Treatment of compounds (25)-(31) with sodium hydride and copper(I) bromide in dimethylformamide afforded methyl 2,3-dihydro-6,7-dimethoxy-1H-pyrroloindole-9-carboxylate (34) and the methyl (+/-)-trans-1-acetoxy-2-(N-ethoxycarbonyl-N-methylamino)-2,3-dihydro-1H-pyrroloindole-9-carboxylates (35)-(37) in good yields.Methyl (+/-)-trans-1-acethoxy-2-(N-ethoxycarbonyl-N-methylamino)-2,3-dihydro-7-methoxy-6-methyl-1H-pyrroloindole-9-carboxylate (36) was converted into the 5,8-quinone (3), via the 8-nitro-compound (38).