57381-51-8Relevant articles and documents
Process for the preparation of chlorinated and fluorinated benzene compounds by selective nucleophilic fluorodenitration
-
, (2008/06/13)
A process for the preparation of chlorinated and fluorinated benzene compounds of the general formula (1) STR1 in which R denotes --CN or --COOalkyl(C1 -C6), and X and Y each denote chlorine or fluorine, X and Y being not identical, by fluorodenitration, which comprises reacting a compound of the formula (2) STR2 in which R is defined as above, and X' and Y' each denote chlorine or nitro, X' and Y' being nor identical, with potassium fluoride in a dipolar aprotic solvent in the presence of a transfer catalyst at a temperature from about 50° C. to about 250° C.
Further Studies on the Synthesis of Quinazolines from 2-Fluorobenzonitriles
Hynes, John B.,Tomazic, Alenka,Parrish, Christie A.,Fetzer, Oliver S.
, p. 1357 - 1364 (2007/10/02)
Recently, we reported that appropriately substituted 2-fluorobenzonitriles undergo cyclization with guanidine carbonate to afford 2,4-diaminoquinazolines usually in good to excellent yield.This paper describes the preparation of a variety of new 2,4-diaminoquinazolines substituted at positions five or seven.In addition, the reactions of selected 2-fluorobenzonitriles with formamidine acetate or acetamidine acetate were examined.The results obtained demonstrate that the analogous 4-amino- and 2-methyl-4-aminoquinazolines can be prepared by this approach but that yields are considerably lower than when guanidine carbonate is employed as the cyclization reagent.