5739-39-9

Basic information

• Product Name: 3-(4-CHLOROPHENYL)PROPIOPHENONE
• Synonyms: 3-(4-CHLOROPHENYL)PROPIOPHENONE;3-(4-chlorophenyl)-1-phenyl-propan-1-one;3-(4-chlorophenyl)-1-phenylpropan-1-one
• CAS NO: 5739-39-9
• Molecular Formula: C₁₅H₁₃ClO
• Molecular Weight: 244.72
• Mol File: 5739-39-9.mol
• Article Data: 128

Chemical Properties

• Boiling Point: 381.3°C at 760 mmHg
• Flash Point: 213°C
• Appearance: /
• Density: 1.164g/cm³
• Vapor Pressure: 5.14E-06mmHg at 25°C
• Refractive Index: 1.583
• CAS DataBase Reference: 3-(4-CHLOROPHENYL)PROPIOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-CHLOROPHENYL)PROPIOPHENONE(5739-39-9)
• EPA Substance Registry System: 3-(4-CHLOROPHENYL)PROPIOPHENONE(5739-39-9)

Safety Data

• Hazardous Substances Data: 5739-39-9(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Synthetic Communications, 19, p. 97, 1989 DOI: 10.1080/00397918908050957

InChI:InChI=1/C15H13ClO/c16-14-9-6-12(7-10-14)8-11-15(17)13-4-2-1-3-5-13/h1-7,9-10H,8,11H2

Upstream product

• 859189-07-4 2-(4-chlorobenzyl)-3-oxo-3-phenylpropionic acid ethyl ester 
• 52085-96-8 3-(4-chlorophenyl)propanoyl chloride 
• 71-43-2 benzene 
• 98-86-2 acetophenone 
• 873-76-7 para-Chlorobenzyl alcohol 
• 956-04-7 3-(4-chlorophenyl)-1-phenylprop-2-en-1-one 
• 82572-06-3 P,P-diphenyl-N-(1-phenylethylidene)phosphinic amide 
• 34544-99-5 2-Benzenesulfonyl-3-(4-chloro-phenyl)-1-phenyl-propan-1-one 
• 123558-66-7 (Z)-3-(4-Chloro-phenyl)-2-methanesulfonyl-1-phenyl-propenone 
• 123558-70-3 3-(4-Chloro-phenyl)-2-methanesulfonyl-1-phenyl-propan-1-one 
• 7664-93-9 sulfuric acid 
• 24721-26-4 4-chlorochalcone 
• 75400-53-2 9-[2-(4-Chloro-phenyl)-ethyl]-9-bora-bicyclo[3.3.1]nonane 
• 380451-93-4 thiobenzoic acid S-(2-morpholin-4-yl-2-oxo-ethyl) ester 

Downstream Products

• 854867-66-6 3-(4-chloro-benzyl)-2-phenyl-quinoline-4-carboxylic acid 
• 113478-79-8 2-bromo-3-(4-chlorophenyl)-1-phenylpropane-1-one 
• 113530-94-2 2-(4-Chloro-benzyl)-3-phenyl-1,2-dihydro-quinoxaline 
• 1180676-62-3 ethyl 5-(4-chlorophenyl)-3-phenylpent-2-enoate 
• 1180676-61-2 ethyl 5-(4-chlorophenyl)-3-phenylpent-2-enoate 
• 1221963-27-4 (Z)-5-(4-chlorophenyl)-3-phenylpent-2-enenitrile 
• 1221963-28-5 (E)-5-(4-chlorophenyl)-3-phenylpent-2-enenitrile 
• 1180676-32-7 PS 48 
• 1402229-05-3 4-((4-amino-5-benzoyl-6-(4-chlorophenyl)-2-morpholinopyridin-3-yl)diazenyl)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one 
• 93-89-0 benzoic acid ethyl ester 
• 24721-26-4 4-chlorochalcone 

Relevant articles and documents

Selective C-C bonds formation, N-alkylation and benzo[d]imidazoles synthesis by a recyclable zinc composite

Earth abundant metals are much less expensive, promising, valuable metals and could be served as catalysts for the borrowing hydrogen reaction, dehydrogenation and heterocycles synthesis, instead of noble metals. The uniformly dispersed zinc composites were designed, synthesized and carefully characterized by means of XPS, EDS, TEM and XRD. The resulting zinc composite showed good catalytic activity for the N-alkylation of amines with amines, ketones with alcohols in water under base-free conditions, while unsaturated carbonyl compounds could also be synthesized by tuning the reaction conditions. Importantly, it was the first time to realize the synthesis of 2-aryl-1H-benzo[d]imidazole derivatives by using this zinc composite under green conditions. Meanwhile, this zinc catalyst could be easily recovered and reused for at least five times.

Nickel-catalyzed α-alkylation of ketones with benzyl alcohols

We reported an efficient method for α-alkylation of ketones with benzyl alcohols using the pyridine-bridged pincer-type N-heterocyclic carbenes nickel complexes as catalysts. A wide range of ketones and benzyl alcohols were efficiently converted into various alkylated products in moderate to high yields. In addition, these nickel complexes were also successfully applied for the synthesis of a wide range of quinoline derivatives.

Chemoselective reduction of ?,￠-unsaturated carbonyl and carboxylic compounds by hydrogen iodide

The selective reduction of ?,￠-unsaturated carbonyl compounds was achieved to produce saturated carbonyl compounds with aqueous HI solution. The introduction of an aryl group at an ? or ￠ position efficiently facilitated the reduction with good yield. The reaction was applicable to compounds bearing carboxylic acids and halogen atoms. Through the investigation of the reaction mechanism, it was found that Michael-type addition of iodide occurred to produce ￠-iodo compounds followed by the reduction of C-I bond via anionic and radical paths.