57625-74-8Relevant articles and documents
Nitrone Formation by Reaction of an Enolate with a Nitro Group
Shimizu, Hiroaki,Yoshinaga, Kohei,Yokoshima, Satoshi
supporting information, p. 2704 - 2709 (2021/04/12)
Ketones with a 2-nitrophenyl group at the α-position were treated with sodium hydroxide in methanol at 60 °C. Under these conditions, enolates derived from the ketones intramolecularly reacted with the nitro group to form a variety of nitrones. Additional experimental results, including the unexpected isolation of N-hydroxyindolinone as a byproduct, led to a proposed reaction mechanism, occurring via an α-hydroxyketone. The resultant nitrones underwent inter- and intramolecular 1,3-dipolar cycloaddition with olefins to afford polycyclic isoxazolidines.
Preparation method of aromatic hydrocarbon compound
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Paragraph 0062-0065, (2020/12/30)
The invention relates to a preparation method of an aromatic hydrocarbon compound, and particularly discloses a preparation method of a compound as shown in a formula I. The preparation method comprises the following step: in trifluoroacetic acid, under the action of triethylsilane, carrying out a reduction reaction as shown in the specification on a compound as shown in a formula II. The invention further discloses a preparation method of the compound 1, wherein the preparation method is simple in raw material, simple and convenient to operate, low in equipment requirement, small in environmental pollution, low in cost and very suitable for industrial production.
Harnessing Applied Potential: Selective β-Hydrocarboxylation of Substituted Olefins
Alkayal, Anas,Buckley, Benjamin R.,Malkov, Andrei V.,Montanaro, Stephanie,Tabas, Volodymyr,Wright, Iain A.
supporting information, (2020/02/13)
The construction of carboxylic acid compounds in a selective fashion from low value materials such as alkenes remains a long-standing challenge to synthetic chemists. In particular, β-addition to styrenes is underdeveloped. Herein we report a new electrosynthetic approach to the selective hydrocarboxylation of alkenes that overcomes the limitations of current transition metal and photochemical approaches. The reported method allows unprecedented direct access to carboxylic acids derived from β,β-trisubstituted alkenes, in a highly regioselective manner.