57753-80-7

Basic information

• Product Name: 2-Furancarbonyl chloride, 5-(4-chlorophenyl)-
• CAS NO: 57753-80-7
• Molecular Formula: C11H6Cl2O2
• Molecular Weight: 241.073
• Mol File: 57753-80-7.mol
• Article Data: 23

Chemical Properties

• CAS DataBase Reference: 2-Furancarbonyl chloride, 5-(4-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Furancarbonyl chloride, 5-(4-chlorophenyl)-(57753-80-7)
• EPA Substance Registry System: 2-Furancarbonyl chloride, 5-(4-chlorophenyl)-(57753-80-7)

Safety Data

• Hazardous Substances Data: 57753-80-7(Hazardous Substances Data)

Upstream product

• 41019-45-8 5-(4-chlorophenyl)-2-furoic acid 
• 41019-40-3 methyl 5-(4-chlorophenyl)furan-2-carboxylate 
• 2527-99-3 methyl 5-bromo-2-furoate 
• 1679-18-1 4-Chlorophenylboronic acid 
• 106-47-8 4-chloro-aniline 
• 88-14-2 2-furanoic acid 

Downstream Products

• 92973-15-4 {[5-(4-Chloro-phenyl)-furan-2-carbonyl]-amino}-acetic acid ethyl ester 
• 364331-66-8 1-(4-methoxyphenyloxyacetyl)-4-(5-(4-chlorophenyl)-2-furoyl)thiosemicarbazide 
• 364331-64-6 1-(4-methylphenyloxyacetyl)-4-(5-(4-chlorophenyl)-2-furoyl)thiosemicarbazide 
• 364331-62-4 1-(2-methylphenyloxyacetyl)-4-(5-(4-chlorophenyl)-2-furoyl)thiosemicarbazide 
• 364331-74-8 1-(1-naphthyloxyacetyl)-4-(5-(4-chlorophenyl)-2-furoyl)thiosemicarbazide 
• 364331-72-6 1-(4-nitrophenyloxyacetyl)-4-(5-(4-chlorophenyl)-2-furoyl)thiosemicarbazide 
• 364331-68-0 1-(2-nitrophenyloxyacetyl)-4-(5-(4-chlorophenyl)-2-furoyl)thiosemicarbazide 
• 364331-70-4 1-(3-nitrophenyloxyacetyl)-4-(5-(4-chlorophenyl)-2-furoyl)thiosemicarbazide 
• 364331-60-2 1-phenyloxyacetyl-4-(5-(4-chlorophenyl)-2-furoyl)thiosemicarbazide 
• 364331-76-0 1-(4-chlorophenyloxyacetyl)-4-(5-(4-chlorophenyl)-2-furoyl)thiosemicarbazide 

Relevant articles and documents

Scaffold Hopping from Amodiaquine to Novel Nurr1 Agonist Chemotypes via Microscale Analogue Libraries

Several lines of evidence suggest the ligand-sensing transcription factor Nurr1 as a promising target to treat neurodegenerative diseases. Nurr1 modulators to validate and exploit this therapeutic potential are rare, however. To identify novel Nurr1 agonist chemotypes, we have employed the Nurr1 activator amodiaquine as template for microscale analogue library synthesis. The first set of analogues was based on the 7-chloroquiolin-4-amine core fragment of amodiaquine and revealed superior N-substituents compared to diethylaminomethylphenol contained in the template. A second library of analogues was subsequently prepared to replace the chloroquinolineamine scaffold. The two sets of analogues enabled a full scaffold hop from amodiaquine to a novel Nurr1 agonist sharing no structural features with the lead but comprising superior potency on Nurr1. Additionally, pharmacophore modeling based on the entire set of active and inactive analogues suggested key features for Nurr1 agonists.

Thiazolidin-2-cyanamides derivatives as novel potent Escherichia coli β-glucuronidase inhibitors and their structure–inhibitory activity relationships

Gut microbial β-glucuronidases have the ability to deconjugate glucuronides of some drugs, thus have been considered as an important drug target to alleviate the drug metabolites-induced gastrointestinal toxicity. In this study, thiazolidin-2-cyanamide de

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The synthesis and biological evaluation as potential urotensin-II receptor antagonists of a series of 5-arylfuran-2-carboxamide derivatives 1, bearing a 4-(3-chloro-4-(piperidin-4-yloxy)benzyl)piperazin-1-yl group, are described. The results of a systemat