57772-03-9Relevant articles and documents
Palladium-Catalyzed Amination of C-5 Bromoimidazo[2,1-b][1,3,4]thiadiazoles
Copin, Chloé,Buron, Frédéric,Routier, Sylvain
, p. 1958 - 1962 (2016/04/26)
A new and efficient palladium-catalyzed amination of imidazo[2,1-b][1,3,4]thiadiazole at the C-5 position under microwave irradiation is reported. The reactivity toward bromine release at the C-5 position was investigated, and palladium-catalyzed cross-co
Synthesis of imidazothiadiazole-benzimidazole conjugates as mitochondrial apoptosis inducers
Kamal, Ahmed,Ponnampalli, Swapna,Vishnuvardhan,Rao, M. P. Narasimha,Mullagiri, Kishore,Nayak, V Lakshma,Chandrakant, Bagul
supporting information, p. 1644 - 1650 (2014/12/11)
A series of imidazothiadiazole-benzimidazole conjugates (3a-z) were synthesized and evaluated for their cytotoxic activity against a set of four selected human cancer cell lines. Amongst them, compounds 3b and 3y exhibited significant antiproliferative activity in ME-180 (cervical) cell line. Flow cytometric analysis showed that these two compounds arrested the cell cycle in the G0/G1 phase leading to the loss of mitochondrial membrane potential followed by apoptotic cell death. Further, Hoechst 33258 staining, DNA fragmentation assay, Annexin V staining assay and caspase-3 also suggested that 3b and 3y induced cell death by apoptosis. Docking studies revealed that compound 3b binds to the Gly142, Phe101, Asn140 and Arg143 on B-cell lymphoma 2 (Bcl-2) proteins and inhibition of Bcl-2 protein could be the possible mechanism of action for these compounds.
Synthesis of imidazo[2,1-b[-1,3,4-thiadiazoles in DABCO as an efficient and recyclable catalyst
Tiwari, Kamleshwar,Verma, Pankaj Kumar,Singh, Shyam Babu,Singh, Jagdamba
experimental part, p. 3021 - 3030 (2012/07/28)
An efficient and general method has been described for the synthesis of imidazo[2,1-b]-1,3,4-thiadiazole by the reaction of 2-aminothiadiazoles with phenacyl bromides in the presence of 1,4-diazabicyclo[2.2.2]octane (DABCO). The method is suitable for the synthesis of functionalized imidazothiadiazoles.