57778-93-5 Usage
Description
3-Aminoindole HCl, also known as 3-Amino-1H-indole hydrochloride, is a chemical compound that features an indole ring structure with an amino group attached at the third carbon position. 3-AMINOINDOLE HCL is recognized for its role as a building block in the synthesis of pharmaceuticals, dyes, and agrochemicals. The hydrochloride (HCl) salt form of 3-Aminoindole enhances its solubility and stability, facilitating easier handling and storage in laboratory environments. Moreover, 3-Aminoindole HCl serves as a valuable research tool in medicinal chemistry and has been investigated for its potential therapeutic applications in treating diseases like cancer and neurodegenerative disorders.
Uses
Used in Pharmaceutical Synthesis:
3-Aminoindole HCl is utilized as a key building block in the development of various pharmaceuticals. Its unique structure allows for the creation of a wide range of drug candidates, contributing to the advancement of medicinal chemistry.
Used in Dye Production:
In the dye industry, 3-Aminoindole HCl serves as an essential component in the production of different types of dyes. Its chemical properties enable the synthesis of dyes with specific color characteristics and stability.
Used in Agrochemical Development:
3-Aminoindole HCl is also employed in the agrochemical sector, where it is used as a starting material for the synthesis of various agrochemicals. This includes the development of pesticides and other compounds that are crucial for agricultural productivity and crop protection.
Used in Organic Reactions:
As a versatile chemical intermediate, 3-Aminoindole HCl is involved in numerous organic reactions. Its reactivity and functional groups make it suitable for use in various chemical processes, leading to the formation of new compounds with diverse applications.
Used in Medicinal Chemistry Research:
3-Aminoindole HCl is a valuable research tool in the field of medicinal chemistry. It is used in the design and synthesis of new compounds with potential therapeutic properties, aiding in the discovery of novel treatments for various diseases.
Used in Disease Treatment Research:
3-Aminoindole HCl has been researched for its potential applications in the treatment of various diseases, such as cancer and neurodegenerative disorders. Its unique chemical structure and properties make it a promising candidate for the development of new therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 57778-93-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,7,7 and 8 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 57778-93:
(7*5)+(6*7)+(5*7)+(4*7)+(3*8)+(2*9)+(1*3)=185
185 % 10 = 5
So 57778-93-5 is a valid CAS Registry Number.
InChI:InChI=1/C8H8N2.ClH/c9-7-5-10-8-4-2-1-3-6(7)8;/h1-5,10H,9H2;1H
57778-93-5Relevant articles and documents
OXALAMIDE HETEROBYCYCLIC COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY
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Page/Page column 159; 174, (2021/04/10)
This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Said chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) STING activation (e.g., STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions containing the same as well as methods of using and making the same.
Total synthesis of 4-azaeudistomin Y1 and analogues by inverse-electron demand diels-alder reactions of 3-aminoindoles with 1,3,5-triazines
Xu, Guoxing,Zheng, Lianyou,Dang, Qun,Bai, Xu
, p. 743 - 752 (2013/04/23)
A new inverse-electron-demand Diels-Alder (IDA) reaction of 3-aminoindoles as dienophiles was developed for the efficient preparation of 4-aza-β-carbolines in high yields. Because N1-unprotected 3-aminoindoles show poor thermal stability, a one-pot protocol was developed that combines the removal of tert-butoxycarbonyl protecting groups with the IDA reaction. This protocol, using tert-butyl 1H-indol-3-ylcarbamates as reactants, gave the corresponding IDA products in excellent yields. The new IDA methodology was used in a total synthesis of 4-azaeudistomin Y1, which was obtained in 57% overall yield in four steps. Moreover, the chemistry is suitable for the rapid preparation, through either Friedel-Crafts acylation or amide-formation reactions, of analogues that are useful for exploring structure-activity relationships at the C1-position. Georg Thieme Verlag Stuttgart · New York.
