578-68-7 Usage
Description
4-Aminoguinoline, also known as 4-Quinolinamine, is an organic compound with the chemical formula C9H7N2. It is a light brown to grey solid and belongs to the quinoline family of compounds. Due to its unique chemical structure, it possesses potential therapeutic properties and has been explored for various medical applications.
Uses
Used in Pharmaceutical Industry:
4-Aminoguinoline is used as an active pharmaceutical ingredient for the development of anti-malarial drugs, targeting the Plasmodium parasite responsible for malaria. Its efficacy in treating malaria has been recognized, and it serves as a crucial component in the fight against this life-threatening disease.
Additionally, 4-Aminoguinoline has been identified for its potential therapeutic effects on patients suffering from arthritis and related diseases. Its anti-inflammatory and immunomodulatory properties make it a promising candidate for further research and development in the treatment of these conditions.
Synthesis Reference(s)
Journal of Medicinal Chemistry, 43, p. 4667, 2000 DOI: 10.1021/jm0002073Tetrahedron Letters, 39, p. 1313, 1998 DOI: 10.1016/S0040-4039(97)10877-2
Purification Methods
It has been purified by zone refining and recrystallisation from *C6H6, EtOH or H2O. The hydrochloride has m 308o (from MeOH), and the picrate has m 277o (from EtOH). [Albert et al. J Chem Soc 2240 1948, Beilstein 22 III/IV 4611, 22/10 V 341.]
Check Digit Verification of cas no
The CAS Registry Mumber 578-68-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,7 and 8 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 578-68:
(5*5)+(4*7)+(3*8)+(2*6)+(1*8)=97
97 % 10 = 7
So 578-68-7 is a valid CAS Registry Number.
InChI:InChI=1/C9H8N2/c10-8-5-6-11-9-4-2-1-3-7(8)9/h1-6H,(H2,10,11)/p+1
578-68-7Relevant articles and documents
Amide derivatives and nociceptin antagonists
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, (2008/06/13)
The present invention relates to a compound of the formula [1′] wherein R2is lower alkyl optionally substituted by hydroxy, amino and the like, ring B is phenyl, thienyl and the like, E is a single bond, —O—, —S— and the like, ring G is aryl, heterocyclic group and the like, R5is halogen atom, hydroxy, lower alkyl optionally substituted by halogen atom etc., and the like, t is 0 or an integer of 1 to 5, when t is an integer of 2 to 5, each R5may be the same or different, m is 0 or an integer of 1 to 8, and n is 0 or an integer of 1 to 4, and a nociceptin antagonist containing compound [1′] as an active ingredient. The compound [1′] shows, due to nociceptin antagonistic action, analgesic effect against sharp pain such as postoperative pain and the like. The present invention also relates to the use of certain amide derivative inclusive of compound [1′] as a nociceptin antagonist or analgesic.