57898-80-3 Usage
Description
rac N-Desbutyroyl Acebutolol, also known as Acebutolol EP Impurity D, is a significant metabolite derived from Acebutolol (A123800). It plays a crucial role in the pharmacological effects and metabolism of the parent compound, Acebutolol.
Uses
Used in Pharmaceutical Industry:
rac N-Desbutyroyl Acebutolol is used as a metabolite for understanding the pharmacokinetics and pharmacodynamics of Acebutolol (A123800). Its presence and analysis are essential in assessing the drug's efficacy, safety, and potential side effects in patients.
Additionally, rac N-Desbutyroyl Acebutolol may be used as a reference compound in the development and quality control of pharmaceutical formulations containing Acebutolol, ensuring the purity and potency of the drug.
Check Digit Verification of cas no
The CAS Registry Mumber 57898-80-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,8,9 and 8 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 57898-80:
(7*5)+(6*7)+(5*8)+(4*9)+(3*8)+(2*8)+(1*0)=193
193 % 10 = 3
So 57898-80-3 is a valid CAS Registry Number.
57898-80-3Relevant articles and documents
A proposed mechanism for the adverse effects of acebutolol: CES2 and CYP2C19-mediated metabolism and antinuclear antibody production
Muta, Kyotaka,Fukami, Tatsuki,Nakajima, Miki
, p. 659 - 670 (2015)
Acebutolol, a β-adrenergic receptor-blocker, occasionally causes drug-induced lupus erythematosus (DILE). Acebutolol is mainly metabolized to diacetolol. Because metabolic activation has been considered to be related to acebutolol-induced toxicity, we sou